Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges
Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunct...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2013-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000400508&lng=en&tlng=en |
| _version_ | 1797715770444087296 |
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| author | Christopher Steven Eickhoff Brian Anthony Dunn Nicole Lea Sullivan Daniel Fredric Hoft |
| author_facet | Christopher Steven Eickhoff Brian Anthony Dunn Nicole Lea Sullivan Daniel Fredric Hoft |
| author_sort | Christopher Steven Eickhoff |
| collection | DOAJ |
| description | Trypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission. |
| first_indexed | 2024-03-12T08:11:38Z |
| format | Article |
| id | doaj.art-341c1744143343b2adecb8134c0235cf |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:38Z |
| publishDate | 2013-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-341c1744143343b2adecb8134c0235cf2023-09-02T19:06:44ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602013-06-01108450851110.1590/S0074-02762013000400018S0074-02762013000400508Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challengesChristopher Steven EickhoffBrian Anthony DunnNicole Lea SullivanDaniel Fredric HoftTrypanosoma cruzi infects humans when infected triatomine vector excreta contaminate breaks in skin or mucosal surfaces. T. cruzi insect-derived metacyclic trypomastigotes (IMT) invade through gastric mucosa after oral challenges without any visible inflammatory changes, while cutaneous and conjunctival infections result in obvious local physical signs. In this study we compared the infectivity of T. cruzi IMT in mice after cutaneous and oral contaminative challenges simulating natural infections. The 50% infective dose (ID50) for oral challenge was 100 fold lower than the ID50for cutaneous challenge, indicating that oral mucosal transmission is more efficient than cutaneous transmission.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000400508&lng=en&tlng=enTrypanosoma cruzimucosal immunityChagas diseaseanimal disease modelsinfection control |
| spellingShingle | Christopher Steven Eickhoff Brian Anthony Dunn Nicole Lea Sullivan Daniel Fredric Hoft Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges Memorias do Instituto Oswaldo Cruz Trypanosoma cruzi mucosal immunity Chagas disease animal disease models infection control |
| title | Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| title_full | Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| title_fullStr | Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| title_full_unstemmed | Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| title_short | Comparison of the infectivity of Trypanosoma cruzi insect-derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| title_sort | comparison of the infectivity of trypanosoma cruzi insect derived metacyclic trypomastigotes after mucosal and cutaneous contaminative challenges |
| topic | Trypanosoma cruzi mucosal immunity Chagas disease animal disease models infection control |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000400508&lng=en&tlng=en |
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