Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review
Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/rec...
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| Format: | Article |
| Language: | English |
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SciELO
2011-01-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300005 |
| _version_ | 1819014106522320896 |
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| author | AP Oliveira LC Mattos CE Cavasini |
| author_facet | AP Oliveira LC Mattos CE Cavasini |
| author_sort | AP Oliveira |
| collection | DOAJ |
| description | Duffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels in the circulation, as it binds and adsorbs them on the surface of red cells as a reservoir. It plays a "sink" role, which can contribute to homeostasis by removing inflammatory chemokines from circulation as well as maintaining them in plasmatic levels. Chronic Chagas' cardiopathy (CCC) is the most frequent form of the disease. It is an inflammatory disease, in which infiltrated inflammatory cells play an important role in the development and progress of the infection. High chemokine levels in the plasma have been associated with the disease severity in patients with heart failure. In this context, the profile of DARC expression could play an important function as a receptor for chemokines in Chagas' disease, in patients with CCC, as it can modulate damage from this inflammatory disease. |
| first_indexed | 2024-12-21T02:10:34Z |
| format | Article |
| id | doaj.art-341d9d06cdea4d05aa677a5cc5b69ba3 |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-12-21T02:10:34Z |
| publishDate | 2011-01-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-341d9d06cdea4d05aa677a5cc5b69ba32022-12-21T19:19:23ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992011-01-0117326427010.1590/S1678-91992011000300005Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-reviewAP OliveiraLC MattosCE CavasiniDuffy gene (FY) codifies the transmembrane glycoprotein Duffy (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This glycoprotein is polymorphic, and constitutes the antigens of the Duffy histo-blood system which were designated receptors for chemokines and denominated DARC (Duffy antigen/receptor for chemokine). This receptor has an important role in the regulation of chemokine levels in the circulation, as it binds and adsorbs them on the surface of red cells as a reservoir. It plays a "sink" role, which can contribute to homeostasis by removing inflammatory chemokines from circulation as well as maintaining them in plasmatic levels. Chronic Chagas' cardiopathy (CCC) is the most frequent form of the disease. It is an inflammatory disease, in which infiltrated inflammatory cells play an important role in the development and progress of the infection. High chemokine levels in the plasma have been associated with the disease severity in patients with heart failure. In this context, the profile of DARC expression could play an important function as a receptor for chemokines in Chagas' disease, in patients with CCC, as it can modulate damage from this inflammatory disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300005DARC antigenDuffy blood-group systemChagas' diseaseChagas' cardiomyopathy |
| spellingShingle | AP Oliveira LC Mattos CE Cavasini Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review Journal of Venomous Animals and Toxins including Tropical Diseases DARC antigen Duffy blood-group system Chagas' disease Chagas' cardiomyopathy |
| title | Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review |
| title_full | Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review |
| title_fullStr | Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review |
| title_full_unstemmed | Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review |
| title_short | Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review |
| title_sort | chagas disease and duffy antigen receptor for chemokine darc a mini review |
| topic | DARC antigen Duffy blood-group system Chagas' disease Chagas' cardiomyopathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300005 |
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