The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases
The brain-gut axis represents a complex bi-directional system comprising multiple interconnections between the neuroendocrine pathways, the autonomous nervous system and the gastrointestinal tract. Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic, rel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/377 |
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| author | Spyros Peppas Claudia Pansieri Daniele Piovani Silvio Danese Laurent Peyrin-Biroulet Andreas G. Tsantes Enrico Brunetta Argirios E. Tsantes Stefanos Bonovas |
| author_facet | Spyros Peppas Claudia Pansieri Daniele Piovani Silvio Danese Laurent Peyrin-Biroulet Andreas G. Tsantes Enrico Brunetta Argirios E. Tsantes Stefanos Bonovas |
| author_sort | Spyros Peppas |
| collection | DOAJ |
| description | The brain-gut axis represents a complex bi-directional system comprising multiple interconnections between the neuroendocrine pathways, the autonomous nervous system and the gastrointestinal tract. Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic, relapsing-remitting inflammatory disorder of the gastrointestinal tract with a multifactorial etiology. Depression and anxiety are prevalent among patients with chronic disorders characterized by a strong immune component, such as diabetes mellitus, cancer, multiple sclerosis, rheumatoid arthritis and IBD. Although psychological problems are an important aspect of morbidity and of impaired quality of life in patients with IBD, depression and anxiety continue to be under-diagnosed. There is lack of evidence regarding the exact mechanisms by which depression, anxiety and cognitive dysfunction may occur in these patients, and whether psychological disorders are the result of disease activity or determinants of the IBD occurrence. In this comprehensive review, we summarize the role of the brain-gut axis in the psychological functioning of patients with IBD, and discuss current preclinical and clinical data on the topic and therapeutic strategies potentially useful for the clinical management of these patients. Personalized pathways of psychological supports are needed to improve the quality of life in patients with IBD. |
| first_indexed | 2024-03-09T04:14:52Z |
| format | Article |
| id | doaj.art-341fd9a6966244679f305c5644aea243 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:14:52Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-341fd9a6966244679f305c5644aea2432023-12-03T13:55:08ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110337710.3390/jcm10030377The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel DiseasesSpyros Peppas0Claudia Pansieri1Daniele Piovani2Silvio Danese3Laurent Peyrin-Biroulet4Andreas G. Tsantes5Enrico Brunetta6Argirios E. Tsantes7Stefanos Bonovas8Department of Gastroenterology, Athens Naval Hospital, 11521 Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, 20090 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, 20090 Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, 20090 Milan, ItalyDepartment of Gastroenterology, Inserm U1256 NGERE, Nancy University Hospital, Lorraine University, 54500 Vandoeuvre-les-Nancy, FranceAttiko Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, 20090 Milan, ItalyAttiko Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, 20090 Milan, ItalyThe brain-gut axis represents a complex bi-directional system comprising multiple interconnections between the neuroendocrine pathways, the autonomous nervous system and the gastrointestinal tract. Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic, relapsing-remitting inflammatory disorder of the gastrointestinal tract with a multifactorial etiology. Depression and anxiety are prevalent among patients with chronic disorders characterized by a strong immune component, such as diabetes mellitus, cancer, multiple sclerosis, rheumatoid arthritis and IBD. Although psychological problems are an important aspect of morbidity and of impaired quality of life in patients with IBD, depression and anxiety continue to be under-diagnosed. There is lack of evidence regarding the exact mechanisms by which depression, anxiety and cognitive dysfunction may occur in these patients, and whether psychological disorders are the result of disease activity or determinants of the IBD occurrence. In this comprehensive review, we summarize the role of the brain-gut axis in the psychological functioning of patients with IBD, and discuss current preclinical and clinical data on the topic and therapeutic strategies potentially useful for the clinical management of these patients. Personalized pathways of psychological supports are needed to improve the quality of life in patients with IBD.https://www.mdpi.com/2077-0383/10/3/377neuropsychologygastroenterologyinflammatory bowel diseasesmental disordersanti-depressive agents |
| spellingShingle | Spyros Peppas Claudia Pansieri Daniele Piovani Silvio Danese Laurent Peyrin-Biroulet Andreas G. Tsantes Enrico Brunetta Argirios E. Tsantes Stefanos Bonovas The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases Journal of Clinical Medicine neuropsychology gastroenterology inflammatory bowel diseases mental disorders anti-depressive agents |
| title | The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases |
| title_full | The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases |
| title_fullStr | The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases |
| title_full_unstemmed | The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases |
| title_short | The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases |
| title_sort | brain gut axis psychological functioning and inflammatory bowel diseases |
| topic | neuropsychology gastroenterology inflammatory bowel diseases mental disorders anti-depressive agents |
| url | https://www.mdpi.com/2077-0383/10/3/377 |
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