Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease
Objective: Behçet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the prese...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2019-08-01
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| Series: | Anatolian Journal of Cardiology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-70019 |
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| author | Şıho Hidayet Vahit Demir Yaşar Turan Gülhan Gürel Mehmet Hakan Taşolar |
| author_facet | Şıho Hidayet Vahit Demir Yaşar Turan Gülhan Gürel Mehmet Hakan Taşolar |
| author_sort | Şıho Hidayet |
| collection | DOAJ |
| description | Objective: Behçet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD.
Methods: A total of 42 patients (mean age: 42.71+-10.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.24+-11.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tp–e interval, and the QT, QTc, Tp e/QT, and Tp–e/QTc ratios.
Results: QTmax (p=0.005), QTcmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tp–e, cTp–e, Tp–e/QT, and Tp–e/QTc ratios were also significantly higher in patients with BD than in the control group (80.26+-4.55 and 74.74+-6.47, respectively, p<0.001; 88.23+-6.36 and 82.68+-7.81, respectively, p<0.001; 0.21+-0.01 and 0.20+-0.01, respectively, p=0.008; and 0.19+-0.01 and 0.18+-0.01, respectively, p=0.01). Positive correlations were found between Tp–e/QTc ratio and disease duration (r=0.382, p=0.013).
Conclusion: Our study showed that the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tp–e/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular arrhythmias. |
| first_indexed | 2024-04-10T10:18:39Z |
| format | Article |
| id | doaj.art-3421b88303a74ab8a659b846e95672fb |
| institution | Directory Open Access Journal |
| issn | 2149-2263 |
| language | English |
| last_indexed | 2024-04-10T10:18:39Z |
| publishDate | 2019-08-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-3421b88303a74ab8a659b846e95672fb2023-02-15T16:21:45ZengKARE PublishingAnatolian Journal of Cardiology2149-22632019-08-01222859010.14744/AnatolJCardiol.2019.70019AJC-70019Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's diseaseŞıho Hidayet0Vahit Demir1Yaşar Turan2Gülhan Gürel3Mehmet Hakan Taşolar4Department of Cardiology, Faculty of Medicine, İnönü University; Malatya-TurkeyDepartment of Cardiology, Faculty of Medicine, Bozok University, Yozgat-TurkeyDepartment of Cardiology, Faculty of Medicine, Bozok University, Yozgat-TurkeyDepartment of Dermatology, Faculty of Medicine, Bozok University, Yozgat-TurkeyDepartment of Cardiology, Faculty of Medicine, İnönü University; Malatya-TurkeyObjective: Behçet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD. Methods: A total of 42 patients (mean age: 42.71+-10.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.24+-11.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tp–e interval, and the QT, QTc, Tp e/QT, and Tp–e/QTc ratios. Results: QTmax (p=0.005), QTcmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tp–e, cTp–e, Tp–e/QT, and Tp–e/QTc ratios were also significantly higher in patients with BD than in the control group (80.26+-4.55 and 74.74+-6.47, respectively, p<0.001; 88.23+-6.36 and 82.68+-7.81, respectively, p<0.001; 0.21+-0.01 and 0.20+-0.01, respectively, p=0.008; and 0.19+-0.01 and 0.18+-0.01, respectively, p=0.01). Positive correlations were found between Tp–e/QTc ratio and disease duration (r=0.382, p=0.013). Conclusion: Our study showed that the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tp–e/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular arrhythmias.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-70019behçet's diseasetp–e intervaltp–e/qtd ratioventricular arrhythmia |
| spellingShingle | Şıho Hidayet Vahit Demir Yaşar Turan Gülhan Gürel Mehmet Hakan Taşolar Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease Anatolian Journal of Cardiology behçet's disease tp–e interval tp–e/qtd ratio ventricular arrhythmia |
| title | Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease |
| title_full | Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease |
| title_fullStr | Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease |
| title_full_unstemmed | Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease |
| title_short | Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet's disease |
| title_sort | evaluation of tp e interval tp e qt ratio and tp e qtc ratio in patients with behcet s disease |
| topic | behçet's disease tp–e interval tp–e/qtd ratio ventricular arrhythmia |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-70019 |
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