Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome
Objective: To investigate the predictive value of lung ultrasound score (LUS) in the extubation failure from mechanical ventilation (MV) among premature infants with neonatal respiratory distress syndrome (RDS).Methods: The retrospective cohort study was conducted with a total of 314 RDS newborns wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.709160/full |
| _version_ | 1819040099730456576 |
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| author | Zhenyu Liang Qiong Meng Chuming You Bijun Wu Xia Li Qianmei Wu |
| author_facet | Zhenyu Liang Qiong Meng Chuming You Bijun Wu Xia Li Qianmei Wu |
| author_sort | Zhenyu Liang |
| collection | DOAJ |
| description | Objective: To investigate the predictive value of lung ultrasound score (LUS) in the extubation failure from mechanical ventilation (MV) among premature infants with neonatal respiratory distress syndrome (RDS).Methods: The retrospective cohort study was conducted with a total of 314 RDS newborns who received MV support for over 24 h. After extubation from MV, infants were divided into extubation success and extubation failure groups. Extubation failure was defined as re-intubation within 48 h after extubation. Univariate and multivariate logistic regression analyses were used to identify the predictors of the extubation failure. The predictive effectiveness of the combined model and LUS in the extubation failure was assessed by receiver operating characteristic curve, area under curve (AUC), and internal validation.Results: 106 infants failed extubation from MV. The combined model for predicting the extubation failure was performed according to the predictors of gestational age, body length, birth weight, and LUS. The AUC of this combined model was 0.871 (sensitivity: 86.67%, specificity: 74.31%). The AUC of LUS was 0.858 (sensitivity: 84.00%, specificity: 80.69%), and the cutoff value was 18. There was no statistical difference in the predictive power between the combined model and LUS (Z = 0.880, P = 0.379). The internal validation result showed that the AUC of LUS was 0.855.Conclusions: LUS presented a good ability in predicting the extubation failure among RDS newborns after MV. |
| first_indexed | 2024-12-21T09:03:43Z |
| format | Article |
| id | doaj.art-34229384dbfc40209fd2a1e0efae4b4e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-21T09:03:43Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-34229384dbfc40209fd2a1e0efae4b4e2022-12-21T19:09:24ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-12-01910.3389/fped.2021.709160709160Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress SyndromeZhenyu Liang0Qiong Meng1Chuming You2Bijun Wu3Xia Li4Qianmei Wu5Department of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaUltrasonic Department, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaObjective: To investigate the predictive value of lung ultrasound score (LUS) in the extubation failure from mechanical ventilation (MV) among premature infants with neonatal respiratory distress syndrome (RDS).Methods: The retrospective cohort study was conducted with a total of 314 RDS newborns who received MV support for over 24 h. After extubation from MV, infants were divided into extubation success and extubation failure groups. Extubation failure was defined as re-intubation within 48 h after extubation. Univariate and multivariate logistic regression analyses were used to identify the predictors of the extubation failure. The predictive effectiveness of the combined model and LUS in the extubation failure was assessed by receiver operating characteristic curve, area under curve (AUC), and internal validation.Results: 106 infants failed extubation from MV. The combined model for predicting the extubation failure was performed according to the predictors of gestational age, body length, birth weight, and LUS. The AUC of this combined model was 0.871 (sensitivity: 86.67%, specificity: 74.31%). The AUC of LUS was 0.858 (sensitivity: 84.00%, specificity: 80.69%), and the cutoff value was 18. There was no statistical difference in the predictive power between the combined model and LUS (Z = 0.880, P = 0.379). The internal validation result showed that the AUC of LUS was 0.855.Conclusions: LUS presented a good ability in predicting the extubation failure among RDS newborns after MV.https://www.frontiersin.org/articles/10.3389/fped.2021.709160/fulllung ultrasound scorepremature infantsneonatal respiratory distress syndromemechanical ventilationpulmonary |
| spellingShingle | Zhenyu Liang Qiong Meng Chuming You Bijun Wu Xia Li Qianmei Wu Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome Frontiers in Pediatrics lung ultrasound score premature infants neonatal respiratory distress syndrome mechanical ventilation pulmonary |
| title | Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome |
| title_full | Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome |
| title_fullStr | Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome |
| title_full_unstemmed | Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome |
| title_short | Roles of Lung Ultrasound Score in the Extubation Failure From Mechanical Ventilation Among Premature Infants With Neonatal Respiratory Distress Syndrome |
| title_sort | roles of lung ultrasound score in the extubation failure from mechanical ventilation among premature infants with neonatal respiratory distress syndrome |
| topic | lung ultrasound score premature infants neonatal respiratory distress syndrome mechanical ventilation pulmonary |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.709160/full |
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