The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women
Background: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland Universit...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/6/1251 |
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| author | Sebastian Findeklee Lena Urban Romina-Marina Sima Simona Lucia Baus Alexander Halfmann Gudrun Wagenpfeil Erich-Franz Solomayer Bashar Haj Hamoud |
| author_facet | Sebastian Findeklee Lena Urban Romina-Marina Sima Simona Lucia Baus Alexander Halfmann Gudrun Wagenpfeil Erich-Franz Solomayer Bashar Haj Hamoud |
| author_sort | Sebastian Findeklee |
| collection | DOAJ |
| description | Background: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland University Hospital were evaluated. Depending on the microorganisms detected, the swab result was classified as inconspicuous, intermediate, or conspicuous. The SPSS software was used to determine the correlation between the swab result and the outcome of the fertility treatment. Results: Dysbiosis was associated with a worse outcome of fertility treatment. The pregnancy rate with a conspicuous swab was 8.6%, whereas it was 13.4% with an inconspicuous swab. However, this association was not statistically significant. Furthermore, an association of endometriosis with dysbiosis was found. Endometriosis was more frequent with a conspicuous swab result than with an inconspicuous result (21.1% vs. 17.7%), yet the correlation was not statistically significant. However, the absence of lactobacilli was significantly associated with endometriosis (<i>p</i> = 0.021). The association between endometriosis and a lower pregnancy rate was also statistically significant (<i>p</i> = 0.006). Conclusion: The microbiological vaginal and cervical swabs can be used as predictors for the success of fertility treatments. Further studies are needed to assess the impact of transforming a dysbiotic flora into a eubiotic environment on the success of fertility treatments. |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T02:14:15Z |
| publishDate | 2023-05-01 |
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| series | Life |
| spelling | doaj.art-3423d29c8fa94cab9ff77134a700c73e2023-11-18T11:16:41ZengMDPI AGLife2075-17292023-05-01136125110.3390/life13061251The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile WomenSebastian Findeklee0Lena Urban1Romina-Marina Sima2Simona Lucia Baus3Alexander Halfmann4Gudrun Wagenpfeil5Erich-Franz Solomayer6Bashar Haj Hamoud7Department of Obstetrics and Gynecology, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyDepartment of Obstetrics and Gynecology, UMF Carol Davila Bucharest, Bucur Maternity, 050474 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyDepartment of Medical Microbiology and Hygiene, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyInstitute of Medical Biometry, Epidemiology and Medical Informatics, Saarland University Hospital, 66424 Homburg, GermanyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Saarland University Hospital, 66424 Homburg, GermanyBackground: The thesis on which this paper is based intended to investigate whether the result of the microbiological vaginal swab has an influence on the outcome of the fertility treatment. Methods: The microbiological vaginal swabs of patients who received fertility treatment at Saarland University Hospital were evaluated. Depending on the microorganisms detected, the swab result was classified as inconspicuous, intermediate, or conspicuous. The SPSS software was used to determine the correlation between the swab result and the outcome of the fertility treatment. Results: Dysbiosis was associated with a worse outcome of fertility treatment. The pregnancy rate with a conspicuous swab was 8.6%, whereas it was 13.4% with an inconspicuous swab. However, this association was not statistically significant. Furthermore, an association of endometriosis with dysbiosis was found. Endometriosis was more frequent with a conspicuous swab result than with an inconspicuous result (21.1% vs. 17.7%), yet the correlation was not statistically significant. However, the absence of lactobacilli was significantly associated with endometriosis (<i>p</i> = 0.021). The association between endometriosis and a lower pregnancy rate was also statistically significant (<i>p</i> = 0.006). Conclusion: The microbiological vaginal and cervical swabs can be used as predictors for the success of fertility treatments. Further studies are needed to assess the impact of transforming a dysbiotic flora into a eubiotic environment on the success of fertility treatments.https://www.mdpi.com/2075-1729/13/6/1251vaginal microbiomevaginal dysbiosisvaginal swabfertility treatmentendometriosis |
| spellingShingle | Sebastian Findeklee Lena Urban Romina-Marina Sima Simona Lucia Baus Alexander Halfmann Gudrun Wagenpfeil Erich-Franz Solomayer Bashar Haj Hamoud The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women Life vaginal microbiome vaginal dysbiosis vaginal swab fertility treatment endometriosis |
| title | The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women |
| title_full | The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women |
| title_fullStr | The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women |
| title_full_unstemmed | The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women |
| title_short | The Impact of the Microbiological Vaginal Swab on the Reproductive Outcome in Infertile Women |
| title_sort | impact of the microbiological vaginal swab on the reproductive outcome in infertile women |
| topic | vaginal microbiome vaginal dysbiosis vaginal swab fertility treatment endometriosis |
| url | https://www.mdpi.com/2075-1729/13/6/1251 |
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