Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers
Films and fibers of syndiotactic polystyrene (sPS), being amorphous or exhibiting nanoporous crystalline (NC) or dense crystalline phases, were loaded with salicylic acid (SA), a relevant non-volatile antimicrobial molecule. In the first section of the paper, sPS/SA co-crystalline (CC) δ form is cha...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/13/5095 |
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| author | Verdiana Covelli Antonietta Cozzolino Paola Rizzo Manuela Rodriquez Vincenzo Vestuto Alessia Bertamino Christophe Daniel Gaetano Guerra |
| author_facet | Verdiana Covelli Antonietta Cozzolino Paola Rizzo Manuela Rodriquez Vincenzo Vestuto Alessia Bertamino Christophe Daniel Gaetano Guerra |
| author_sort | Verdiana Covelli |
| collection | DOAJ |
| description | Films and fibers of syndiotactic polystyrene (sPS), being amorphous or exhibiting nanoporous crystalline (NC) or dense crystalline phases, were loaded with salicylic acid (SA), a relevant non-volatile antimicrobial molecule. In the first section of the paper, sPS/SA co-crystalline (CC) δ form is characterized, mainly by wide angle X-ray diffraction (WAXD) patterns and polarized Fourier transform infrared (FTIR) spectra. The formation of sPS/SA δ CC phases allows the preparation of sPS fibers even with a high content of the antibacterial guest, which is also retained after repeated washing procedures at 65 °C. A preparation procedure starting from amorphous fibers is particularly appropriate because involves a direct formation of the CC δ form and a simultaneous axial orientation. The possibility of tuning drug amount and release kinetics, by simply selecting suitable crystalline phases of a commercially available polymer, makes sPS fibers possibly useful for many applications. In particular, fibers with δ CC forms, which retain SA molecules in their crystalline phases, could be useful for antimicrobial textiles and fabrics. Fibers with the dense γ form which easily release SA molecules, because they are only included in their amorphous phases, could be used for promising SA-based preparations for antibacterial purposes in food processing and preservation and public health. Finally, using a cell-based assay system and antibacterial tests, we investigated the cellular activity, toxicity and antimicrobial properties of amorphous, δ CC forms and dense γ form of sPS fibers loaded with different contents of SA. |
| first_indexed | 2024-03-11T01:33:59Z |
| format | Article |
| id | doaj.art-3424d28311e045e6af4603efc6cd0339 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T01:33:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3424d28311e045e6af4603efc6cd03392023-11-18T17:08:05ZengMDPI AGMolecules1420-30492023-06-012813509510.3390/molecules28135095Salicylic Acid Release from Syndiotactic Polystyrene Staple FibersVerdiana Covelli0Antonietta Cozzolino1Paola Rizzo2Manuela Rodriquez3Vincenzo Vestuto4Alessia Bertamino5Christophe Daniel6Gaetano Guerra7Department of Chemistry and Biology “A. Zambelli” and INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Chemistry and Biology “A. Zambelli” and INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Chemistry and Biology “A. Zambelli” and INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Pharmacy, University of Napoli, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Chemistry and Biology “A. Zambelli” and INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyDepartment of Chemistry and Biology “A. Zambelli” and INSTM Research Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, ItalyFilms and fibers of syndiotactic polystyrene (sPS), being amorphous or exhibiting nanoporous crystalline (NC) or dense crystalline phases, were loaded with salicylic acid (SA), a relevant non-volatile antimicrobial molecule. In the first section of the paper, sPS/SA co-crystalline (CC) δ form is characterized, mainly by wide angle X-ray diffraction (WAXD) patterns and polarized Fourier transform infrared (FTIR) spectra. The formation of sPS/SA δ CC phases allows the preparation of sPS fibers even with a high content of the antibacterial guest, which is also retained after repeated washing procedures at 65 °C. A preparation procedure starting from amorphous fibers is particularly appropriate because involves a direct formation of the CC δ form and a simultaneous axial orientation. The possibility of tuning drug amount and release kinetics, by simply selecting suitable crystalline phases of a commercially available polymer, makes sPS fibers possibly useful for many applications. In particular, fibers with δ CC forms, which retain SA molecules in their crystalline phases, could be useful for antimicrobial textiles and fabrics. Fibers with the dense γ form which easily release SA molecules, because they are only included in their amorphous phases, could be used for promising SA-based preparations for antibacterial purposes in food processing and preservation and public health. Finally, using a cell-based assay system and antibacterial tests, we investigated the cellular activity, toxicity and antimicrobial properties of amorphous, δ CC forms and dense γ form of sPS fibers loaded with different contents of SA.https://www.mdpi.com/1420-3049/28/13/5095WAXDpolarized FTIR spectradrug releasecellular activity |
| spellingShingle | Verdiana Covelli Antonietta Cozzolino Paola Rizzo Manuela Rodriquez Vincenzo Vestuto Alessia Bertamino Christophe Daniel Gaetano Guerra Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers Molecules WAXD polarized FTIR spectra drug release cellular activity |
| title | Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers |
| title_full | Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers |
| title_fullStr | Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers |
| title_full_unstemmed | Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers |
| title_short | Salicylic Acid Release from Syndiotactic Polystyrene Staple Fibers |
| title_sort | salicylic acid release from syndiotactic polystyrene staple fibers |
| topic | WAXD polarized FTIR spectra drug release cellular activity |
| url | https://www.mdpi.com/1420-3049/28/13/5095 |
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