Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China
BackgroundThe sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recently suggested to be a reliable marker for sarcopenia. It has been reported that sarcopenia is associated with poorer cognition. The purpose of this study was to evaluate the correlation between SI and cognitive func...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.919430/full |
| _version_ | 1811209736793620480 |
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| author | Yueli Zhu Zhongju Tan Shumin Li Feng Zhu Chengfan Qin Qin Zhang Qin Zhang Yunmei Yang Yunmei Yang |
| author_facet | Yueli Zhu Zhongju Tan Shumin Li Feng Zhu Chengfan Qin Qin Zhang Qin Zhang Yunmei Yang Yunmei Yang |
| author_sort | Yueli Zhu |
| collection | DOAJ |
| description | BackgroundThe sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recently suggested to be a reliable marker for sarcopenia. It has been reported that sarcopenia is associated with poorer cognition. The purpose of this study was to evaluate the correlation between SI and cognitive function among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).Materials and methodsA total of 6,442 participants ≥45 years of age were enrolled in this study from CHARLS between 2011 and 2012. Cognitive function was assessed by interview-based measurements, including orientation and attention, episodic memory, visuo-construction, and the total cognitive function. SI was calculated by serum creatinine (mg/dL)/cystatin C (mg/L) × 100. One-way analysis of variance (ANOVA) was used to compare the differences among groups divided according to SI quartiles by gender. Both linear and logistic regression models were applied to investigate the relationship between SI and cognitive function.ResultsAfter adjustment for potential confounders, we found SI was significantly and positively correlated with total cognitive function scores both in males and females [β = 0.014, 95% confidence interval (CI) 0.007 to 0.021, P < 0.001; β = 0.011, 95 CI% 0.003 to 0.018, P = 0.004; respectively]. Similarly, when the total cognitive function score was treated as a categorical variable according to quartiles in males and females, higher SI was related to better total cognitive function scores in both males and females [odds ratio (OR) = 1.147, 95% CI 1.028 to 1.279, P = 0.014; OR = 1.219, 95% CI 1.106 to 1.344, P < 0.001; respectively] following adjustment for confounders.ConclusionsLower sarcopenia index was correlated with a higher prevalence of cognitive impairment among middle-aged and older adults in China. |
| first_indexed | 2024-04-12T04:45:35Z |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T04:45:35Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-342630de55554d12ba373ad68e7224f12022-12-22T03:47:31ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-09-011410.3389/fnagi.2022.919430919430Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in ChinaYueli Zhu0Zhongju Tan1Shumin Li2Feng Zhu3Chengfan Qin4Qin Zhang5Qin Zhang6Yunmei Yang7Yunmei Yang8Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackgroundThe sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recently suggested to be a reliable marker for sarcopenia. It has been reported that sarcopenia is associated with poorer cognition. The purpose of this study was to evaluate the correlation between SI and cognitive function among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).Materials and methodsA total of 6,442 participants ≥45 years of age were enrolled in this study from CHARLS between 2011 and 2012. Cognitive function was assessed by interview-based measurements, including orientation and attention, episodic memory, visuo-construction, and the total cognitive function. SI was calculated by serum creatinine (mg/dL)/cystatin C (mg/L) × 100. One-way analysis of variance (ANOVA) was used to compare the differences among groups divided according to SI quartiles by gender. Both linear and logistic regression models were applied to investigate the relationship between SI and cognitive function.ResultsAfter adjustment for potential confounders, we found SI was significantly and positively correlated with total cognitive function scores both in males and females [β = 0.014, 95% confidence interval (CI) 0.007 to 0.021, P < 0.001; β = 0.011, 95 CI% 0.003 to 0.018, P = 0.004; respectively]. Similarly, when the total cognitive function score was treated as a categorical variable according to quartiles in males and females, higher SI was related to better total cognitive function scores in both males and females [odds ratio (OR) = 1.147, 95% CI 1.028 to 1.279, P = 0.014; OR = 1.219, 95% CI 1.106 to 1.344, P < 0.001; respectively] following adjustment for confounders.ConclusionsLower sarcopenia index was correlated with a higher prevalence of cognitive impairment among middle-aged and older adults in China.https://www.frontiersin.org/articles/10.3389/fnagi.2022.919430/fullcreatininecystatin Ccognitive functionsarcopeniaelders |
| spellingShingle | Yueli Zhu Zhongju Tan Shumin Li Feng Zhu Chengfan Qin Qin Zhang Qin Zhang Yunmei Yang Yunmei Yang Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China Frontiers in Aging Neuroscience creatinine cystatin C cognitive function sarcopenia elders |
| title | Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China |
| title_full | Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China |
| title_fullStr | Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China |
| title_full_unstemmed | Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China |
| title_short | Serum creatinine to cystatin C ratio and cognitive function among middle-aged and older adults in China |
| title_sort | serum creatinine to cystatin c ratio and cognitive function among middle aged and older adults in china |
| topic | creatinine cystatin C cognitive function sarcopenia elders |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.919430/full |
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