SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

NFATc4, a member from the Nuclear Factor of Activated T cells (NFATs) transcription factor family, plays a pivotal role in the development of cardiac hypertrophy. NFATc4 is dephosphorylated by calcineurin and translocated from the cytoplasm to the nucleus to regulate the expression of hypertrophic g...

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Bibliographic Details
Main Authors: Zhenzhen Li, Xiaoying Zhang, Zhen Guo, Yao Zhong, Panxia Wang, Jingyan Li, Zhuoming Li, Peiqing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
cardiomyocyte hypertrophy
SIRT6
deacetylase activity
NFATc4
BNP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01519/full

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