Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery
Two infants treated for syphilis born to at risk mothers who screened negative at their first prenatal visit but were not rescreened at delivery are described. The first presented with classic, but unrecognized, features of congenital syphilis. In the second case, possible early maternal syphilis wa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250920302729 |
| _version_ | 1818906275479552000 |
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| author | Nicola P. O’Connor Blanca E. Gonzalez Frank P. Esper Joan Tamburro Kamran Kadkhoda Charles B. Foster |
| author_facet | Nicola P. O’Connor Blanca E. Gonzalez Frank P. Esper Joan Tamburro Kamran Kadkhoda Charles B. Foster |
| author_sort | Nicola P. O’Connor |
| collection | DOAJ |
| description | Two infants treated for syphilis born to at risk mothers who screened negative at their first prenatal visit but were not rescreened at delivery are described. The first presented with classic, but unrecognized, features of congenital syphilis. In the second case, possible early maternal syphilis was diagnosed soon after delivery using the treponemal first reverse-screening algorithm. Although the child’s physical exam was normal and the maternal rapid plasma reagin (RPR) negative, the child was treated for syphilis because maternal confirmatory treponemal tests suggested recent seroconversion. Given the re-emergence of congenital syphilis, our report aims to demonstrate the importance of rescreening women at increased risk and improve awareness of common manifestations of the syphilis disease in the newborn. For women at increased risk, repeat syphilis testing early in the third trimester and again at delivery in communities and populations with a high prevalence of syphilis is recommended. |
| first_indexed | 2024-12-19T21:36:38Z |
| format | Article |
| id | doaj.art-3429abb108a54ca3acfb9907a9a0e5fd |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-19T21:36:38Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-3429abb108a54ca3acfb9907a9a0e5fd2022-12-21T20:04:46ZengElsevierIDCases2214-25092020-01-0122e00964Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at deliveryNicola P. O’Connor0Blanca E. Gonzalez1Frank P. Esper2Joan Tamburro3Kamran Kadkhoda4Charles B. Foster5Center for Pediatric Infectious Diseases, Cleveland Clinic Children’s, Cleveland Clinic, Cleveland, OH, United StatesCenter for Pediatric Infectious Diseases, Cleveland Clinic Children’s, Cleveland Clinic, Cleveland, OH, United StatesCenter for Pediatric Infectious Diseases, Cleveland Clinic Children’s, Cleveland Clinic, Cleveland, OH, United StatesSection of Pediatric Dermatology, Cleveland Clinic, Cleveland, OH, United StatesRobert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United StatesCenter for Pediatric Infectious Diseases, Cleveland Clinic Children’s, Cleveland Clinic, Cleveland, OH, United States; Corresponding author at: Center for Pediatric Infectious Diseases, Cleveland Clinic Children’s Cleveland Clinic, Cleveland, OH 44195, United States.Two infants treated for syphilis born to at risk mothers who screened negative at their first prenatal visit but were not rescreened at delivery are described. The first presented with classic, but unrecognized, features of congenital syphilis. In the second case, possible early maternal syphilis was diagnosed soon after delivery using the treponemal first reverse-screening algorithm. Although the child’s physical exam was normal and the maternal rapid plasma reagin (RPR) negative, the child was treated for syphilis because maternal confirmatory treponemal tests suggested recent seroconversion. Given the re-emergence of congenital syphilis, our report aims to demonstrate the importance of rescreening women at increased risk and improve awareness of common manifestations of the syphilis disease in the newborn. For women at increased risk, repeat syphilis testing early in the third trimester and again at delivery in communities and populations with a high prevalence of syphilis is recommended.http://www.sciencedirect.com/science/article/pii/S2214250920302729Congenital syphilisCondyloma lataPregnancyReverse-sequence screeningRescreeningDelivery |
| spellingShingle | Nicola P. O’Connor Blanca E. Gonzalez Frank P. Esper Joan Tamburro Kamran Kadkhoda Charles B. Foster Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery IDCases Congenital syphilis Condyloma lata Pregnancy Reverse-sequence screening Rescreening Delivery |
| title | Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery |
| title_full | Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery |
| title_fullStr | Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery |
| title_full_unstemmed | Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery |
| title_short | Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery |
| title_sort | congenital syphilis missed opportunities and the case for rescreening during pregnancy and at delivery |
| topic | Congenital syphilis Condyloma lata Pregnancy Reverse-sequence screening Rescreening Delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2214250920302729 |
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