Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees: A controlled, prospective human clinical trial based on mass spectrometry imaging analysis

Biological injection therapy with leukocyte-poor platelet-rich plasma induces cellular alterations, enhancement of lubricin, and inflammatory downregulation in vivo in human knees: A controlled, prospective human clinical trial based on mass spectrometry imaging analysis

ObjectiveTo investigate the in vivo biological effects of leukocyte-poor platelet-rich plasma (LpPRP) treatment in human synovial layer to establish the cellular basis for a prolonged clinical improvement.MethodsSynovial tissues (n = 367) were prospectively collected from patients undergoing arthros...

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Bibliographic Details
Main Authors: Axel W. Baltzer, Rita Casadonte, Alexei Korff, Lea Merline Baltzer, Katharina Kriegsmann, Mark Kriegsmann, Jörg Kriegsmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Surgery
Subjects:
disease-modifying therapy
inflammation
LpPRP
MALDI-mass spectrometry
osteoarthritis
platelet-rich plasma
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2023.1169112/full

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