Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability

Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability

Abstract Disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional SynGAP1 protein, individuals are developmentally delayed and have prominent features of intellectual disability (ID),...

Full description

Bibliographic Details
Main Authors: Timothy A. Fenton, Olivia Y. Haouchine, Elizabeth B. Hallam, Emily M. Smith, Kiya C. Jackson, Darlene Rahbarian, Cesar P. Canales, Anna Adhikari, Alex S. Nord, Roy Ben-Shalom, Jill L. Silverman
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-03077-6

Internet

https://doi.org/10.1038/s41398-024-03077-6

Similar Items