Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review
Breast cancer treatment can induce alterations in blood- and neuroimaging-based markers. However, an overview of the predictive value of these markers for cognition is lacking for breast cancer survivors.This systematic review summarized studies of the last decade, using the PubMed database, evaluat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523321002886 |
| _version_ | 1831682789582307328 |
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| author | Gwen Schroyen Julie Vissers Ann Smeets Céline R. Gillebert Jurgen Lemiere Stefan Sunaert Sabine Deprez Charlotte Sleurs |
| author_facet | Gwen Schroyen Julie Vissers Ann Smeets Céline R. Gillebert Jurgen Lemiere Stefan Sunaert Sabine Deprez Charlotte Sleurs |
| author_sort | Gwen Schroyen |
| collection | DOAJ |
| description | Breast cancer treatment can induce alterations in blood- and neuroimaging-based markers. However, an overview of the predictive value of these markers for cognition is lacking for breast cancer survivors.This systematic review summarized studies of the last decade, using the PubMed database, evaluating blood markers, and the association between blood- or structural neuroimaging markers and cognition across the chemotherapy trajectory for primary breast cancer, following PRISMA guidelines.Forty-four studies were included. Differences were observed in all blood marker categories, from on-therapy until years post-chemotherapy. Associations were found between cognitive functioning and (1) blood markers (mainly inflammation-related) during, shortly-, or years post-chemotherapy and (2) white and gray matter metrics in frontal, temporal and parietal brain regions months up until years post-chemotherapy. Preliminary evidence exists for epigenetic and metabolic changes being associated with cognition, only after chemotherapy.This review demonstrated time-dependent associations between specific blood-based and structural neuroimaging markers with cognitive impairment in patients with breast cancer. Future studies are encouraged to include both neuroimaging- and blood markers (e.g. of neuronal integrity, epigenetics and metabolism) to predict long-term cognitive effects of chemotherapy. |
| first_indexed | 2024-12-20T06:25:41Z |
| format | Article |
| id | doaj.art-342b464c6de94e5ca5a3abfbbdf9fd49 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-20T06:25:41Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-342b464c6de94e5ca5a3abfbbdf9fd492022-12-21T19:50:18ZengElsevierTranslational Oncology1936-52332022-02-0116101297Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic reviewGwen Schroyen0Julie Vissers1Ann Smeets2Céline R. Gillebert3Jurgen Lemiere4Stefan Sunaert5Sabine Deprez6Charlotte Sleurs7Leuven Brain Institute, KU Leuven, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; Corresponding author at: Radiology, University Hospitals Leuven, UZ Leuven; UZ Herestraat 49 – box 7003, Leuven 3000, Belgium.Department of Imaging and Pathology, KU Leuven, Leuven, BelgiumLeuven Cancer Institute, KU Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Surgical Oncology, University Hospitals Leuven, Leuven, BelgiumLeuven Brain Institute, KU Leuven, Leuven, Belgium; Department of Brain and Cognition, KU Leuven, Leuven 3000, BelgiumLeuven Cancer Institute, KU Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium; Pediatric Hemato-Oncology, University Hospitals Leuven, Leuven 3000, BelgiumLeuven Brain Institute, KU Leuven, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; Radiology, University Hospitals Leuven, Leuven 3000, BelgiumLeuven Brain Institute, KU Leuven, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Leuven, BelgiumLeuven Brain Institute, KU Leuven, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, BelgiumBreast cancer treatment can induce alterations in blood- and neuroimaging-based markers. However, an overview of the predictive value of these markers for cognition is lacking for breast cancer survivors.This systematic review summarized studies of the last decade, using the PubMed database, evaluating blood markers, and the association between blood- or structural neuroimaging markers and cognition across the chemotherapy trajectory for primary breast cancer, following PRISMA guidelines.Forty-four studies were included. Differences were observed in all blood marker categories, from on-therapy until years post-chemotherapy. Associations were found between cognitive functioning and (1) blood markers (mainly inflammation-related) during, shortly-, or years post-chemotherapy and (2) white and gray matter metrics in frontal, temporal and parietal brain regions months up until years post-chemotherapy. Preliminary evidence exists for epigenetic and metabolic changes being associated with cognition, only after chemotherapy.This review demonstrated time-dependent associations between specific blood-based and structural neuroimaging markers with cognitive impairment in patients with breast cancer. Future studies are encouraged to include both neuroimaging- and blood markers (e.g. of neuronal integrity, epigenetics and metabolism) to predict long-term cognitive effects of chemotherapy.http://www.sciencedirect.com/science/article/pii/S1936523321002886NeuroimagingChemotherapyCognitive impairmentBiological markersBreast cancer |
| spellingShingle | Gwen Schroyen Julie Vissers Ann Smeets Céline R. Gillebert Jurgen Lemiere Stefan Sunaert Sabine Deprez Charlotte Sleurs Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review Translational Oncology Neuroimaging Chemotherapy Cognitive impairment Biological markers Breast cancer |
| title | Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review |
| title_full | Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review |
| title_fullStr | Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review |
| title_full_unstemmed | Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review |
| title_short | Blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy: A systematic review |
| title_sort | blood and neuroimaging biomarkers of cognitive sequelae in breast cancer patients throughout chemotherapy a systematic review |
| topic | Neuroimaging Chemotherapy Cognitive impairment Biological markers Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1936523321002886 |
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