Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations
Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit muscle contraction, is central to calcium ion balance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2017-05-01
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| Series: | G3: Genes, Genomes, Genetics |
| Subjects: | |
| Online Access: | http://g3journal.org/lookup/doi/10.1534/g3.117.040535 |
| _version_ | 1818618909342826496 |
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| author | Katie Nicoll Baines Célia Ferreira Philip M. Hopkins Marie-Anne Shaw Ian A. Hope |
| author_facet | Katie Nicoll Baines Célia Ferreira Philip M. Hopkins Marie-Anne Shaw Ian A. Hope |
| author_sort | Katie Nicoll Baines |
| collection | DOAJ |
| description | Delaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit muscle contraction, is central to calcium ion balance and is hypothesized to be a significant factor for age-related decline in muscle function. The nematode Caenorhabditis elegans is a key model system for the study of human aging, and strains were generated with modified C. elegans ryanodine receptors corresponding to human myopathic variants linked with malignant hyperthermia and related conditions. The altered response of these strains to pharmacological agents reflected results of human diagnostic tests for individuals with these pathogenic variants. Involvement of nerve cells in the C. elegans responses may relate to rare medical symptoms concerning the central nervous system that have been associated with ryanodine receptor variants. These single amino acid modifications in C. elegans also conferred a reduction in lifespan and an accelerated decline in muscle integrity with age, supporting the significance of ryanodine receptor function for human aging. |
| first_indexed | 2024-12-16T17:29:05Z |
| format | Article |
| id | doaj.art-342e95e473084d29af3a27c27d81c27d |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-12-16T17:29:05Z |
| publishDate | 2017-05-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-342e95e473084d29af3a27c27d81c27d2022-12-21T22:22:58ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362017-05-01751451146110.1534/g3.117.0405357Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic MutationsKatie Nicoll BainesCélia FerreiraPhilip M. HopkinsMarie-Anne ShawIan A. HopeDelaying the decline in skeletal muscle function will be critical to better maintenance of an active lifestyle in old age. The skeletal muscle ryanodine receptor, the major intracellular membrane channel through which calcium ions pass to elicit muscle contraction, is central to calcium ion balance and is hypothesized to be a significant factor for age-related decline in muscle function. The nematode Caenorhabditis elegans is a key model system for the study of human aging, and strains were generated with modified C. elegans ryanodine receptors corresponding to human myopathic variants linked with malignant hyperthermia and related conditions. The altered response of these strains to pharmacological agents reflected results of human diagnostic tests for individuals with these pathogenic variants. Involvement of nerve cells in the C. elegans responses may relate to rare medical symptoms concerning the central nervous system that have been associated with ryanodine receptor variants. These single amino acid modifications in C. elegans also conferred a reduction in lifespan and an accelerated decline in muscle integrity with age, supporting the significance of ryanodine receptor function for human aging.http://g3journal.org/lookup/doi/10.1534/g3.117.040535Caenorhabditis elegansagingryanodine receptormalignant hyperthermiamuscle |
| spellingShingle | Katie Nicoll Baines Célia Ferreira Philip M. Hopkins Marie-Anne Shaw Ian A. Hope Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations G3: Genes, Genomes, Genetics Caenorhabditis elegans aging ryanodine receptor malignant hyperthermia muscle |
| title | Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations |
| title_full | Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations |
| title_fullStr | Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations |
| title_full_unstemmed | Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations |
| title_short | Aging Effects of Caenorhabditis elegans Ryanodine Receptor Variants Corresponding to Human Myopathic Mutations |
| title_sort | aging effects of caenorhabditis elegans ryanodine receptor variants corresponding to human myopathic mutations |
| topic | Caenorhabditis elegans aging ryanodine receptor malignant hyperthermia muscle |
| url | http://g3journal.org/lookup/doi/10.1534/g3.117.040535 |
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