Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia.</p>...
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/1/120 |
| _version_ | 1818665006160412672 |
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| author | Restrepo Marcos I Mortensen Eric M Pugh Jacqueline A Anzueto Antonio |
| author_facet | Restrepo Marcos I Mortensen Eric M Pugh Jacqueline A Anzueto Antonio |
| author_sort | Restrepo Marcos I |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia.</p> <p>Methods</p> <p>A retrospective cohort study conducted at two tertiary teaching hospitals. Eligible subjects were admitted with a diagnosis of, and had a chest x-ray consistent with, community-acquired pneumonia. Our primary analysis was a multivariable logistic regression with the dependent variable of 30-day mortality.</p> <p>Results</p> <p>Data was abstracted on 733 subjects at the two hospitals. Mortality was 8.1% at 30-days. At presentation, 55% of subjects were low risk, 33% were moderate risk, and 12% were high risk. In our cohort 17% (n = 128) of subjects received antibiotics within 30-days of presentation. Unadjusted mortality for those who had received prior antibiotics was 7.0% vs. 8.3% for those who had not (p = 0.6). In the multivariable analysis prior use of antibiotics (odds ratio 0.98, 95% confidence interval 0.5–2.1) was not significantly associated with 30-day mortality.</p> <p>Conclusion</p> <p>Receipt of prior outpatient antibiotics is not significantly associated with 30-day mortality for patients hospitalized with pneumonia. Our study supports current efforts to increase the number of patients with pneumonia who are treated as outpatients.</p> |
| first_indexed | 2024-12-17T05:41:46Z |
| format | Article |
| id | doaj.art-343234367c964f8a8c713fa4171114fe |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-17T05:41:46Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-343234367c964f8a8c713fa4171114fe2022-12-21T22:01:25ZengBMCBMC Research Notes1756-05002008-12-011112010.1186/1756-0500-1-120Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort studyRestrepo Marcos IMortensen Eric MPugh Jacqueline AAnzueto Antonio<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia.</p> <p>Methods</p> <p>A retrospective cohort study conducted at two tertiary teaching hospitals. Eligible subjects were admitted with a diagnosis of, and had a chest x-ray consistent with, community-acquired pneumonia. Our primary analysis was a multivariable logistic regression with the dependent variable of 30-day mortality.</p> <p>Results</p> <p>Data was abstracted on 733 subjects at the two hospitals. Mortality was 8.1% at 30-days. At presentation, 55% of subjects were low risk, 33% were moderate risk, and 12% were high risk. In our cohort 17% (n = 128) of subjects received antibiotics within 30-days of presentation. Unadjusted mortality for those who had received prior antibiotics was 7.0% vs. 8.3% for those who had not (p = 0.6). In the multivariable analysis prior use of antibiotics (odds ratio 0.98, 95% confidence interval 0.5–2.1) was not significantly associated with 30-day mortality.</p> <p>Conclusion</p> <p>Receipt of prior outpatient antibiotics is not significantly associated with 30-day mortality for patients hospitalized with pneumonia. Our study supports current efforts to increase the number of patients with pneumonia who are treated as outpatients.</p>http://www.biomedcentral.com/1756-0500/1/120 |
| spellingShingle | Restrepo Marcos I Mortensen Eric M Pugh Jacqueline A Anzueto Antonio Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study BMC Research Notes |
| title | Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study |
| title_full | Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study |
| title_fullStr | Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study |
| title_full_unstemmed | Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study |
| title_short | Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort study |
| title_sort | impact of prior outpatient antibiotic use on mortality for community acquired pneumonia a retrospective cohort study |
| url | http://www.biomedcentral.com/1756-0500/1/120 |
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