Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients
Brain natriuretic peptide (BNP) levels increase in patients with congestive heart failure. Theoretically, BNP levels can be helpful in the determination of the "dry weight" of hemodialysis patients. To evaluate the effect of hemodialysis on the plasma concentration of BNP and to determine...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2006-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Subjects: | |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2006;volume=17;issue=2;spage=171;epage=176;aulast=Alsuwaida |
| _version_ | 1818951972996251648 |
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| author | Alsuwaida Abdulkareem |
| author_facet | Alsuwaida Abdulkareem |
| author_sort | Alsuwaida Abdulkareem |
| collection | DOAJ |
| description | Brain natriuretic peptide (BNP) levels increase in patients with congestive heart failure. Theoretically, BNP levels can be helpful in the determination of the "dry weight" of hemodialysis patients. To evaluate the effect of hemodialysis on the plasma concentration of BNP and to determine the factors that affect BNP levels during hemodialysis in patients with chronic renal failure, we studied five stable patients with chronic renal failure. A total of 15 blood samples were obtained for BNP levels at 24, 48 and 72 hours after the last hemodialysis session. The plasma BNP levels did not change significantly either with ultrafiltration volume or with time since last dialysis. However, the BNP levels correlated positively with the erythropoietin (EPO) dose (r=0.98, P< 0.001) and negatively with the serum albumin levels (r = 0.94, P=0.02). Univariate analysis showed that the EPO dose (P=0.001) and the albumin level (P=0.02) were significant predictors of BNP level. Adjusted multivariate analysis showed significant interaction between the EPO dose and the albumin level (P=0.01, P=0.03 respectively. In conclusion: the plasma BNP levels were not significantly influenced by ultrafiltration volume or time since last dialysis. However, the BNP levels may be a useful prognostic parameter for assessing the risk of cardiovascular morbidity and mortality in hemodialysis patients. |
| first_indexed | 2024-12-20T09:42:59Z |
| format | Article |
| id | doaj.art-3433f7ef69bf4ec7a58943a519331648 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-20T09:42:59Z |
| publishDate | 2006-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-3433f7ef69bf4ec7a58943a5193316482022-12-21T19:44:49ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422006-01-01172171176Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis PatientsAlsuwaida AbdulkareemBrain natriuretic peptide (BNP) levels increase in patients with congestive heart failure. Theoretically, BNP levels can be helpful in the determination of the "dry weight" of hemodialysis patients. To evaluate the effect of hemodialysis on the plasma concentration of BNP and to determine the factors that affect BNP levels during hemodialysis in patients with chronic renal failure, we studied five stable patients with chronic renal failure. A total of 15 blood samples were obtained for BNP levels at 24, 48 and 72 hours after the last hemodialysis session. The plasma BNP levels did not change significantly either with ultrafiltration volume or with time since last dialysis. However, the BNP levels correlated positively with the erythropoietin (EPO) dose (r=0.98, P< 0.001) and negatively with the serum albumin levels (r = 0.94, P=0.02). Univariate analysis showed that the EPO dose (P=0.001) and the albumin level (P=0.02) were significant predictors of BNP level. Adjusted multivariate analysis showed significant interaction between the EPO dose and the albumin level (P=0.01, P=0.03 respectively. In conclusion: the plasma BNP levels were not significantly influenced by ultrafiltration volume or time since last dialysis. However, the BNP levels may be a useful prognostic parameter for assessing the risk of cardiovascular morbidity and mortality in hemodialysis patients.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2006;volume=17;issue=2;spage=171;epage=176;aulast=AlsuwaidaBrain natriuretic peptideAlbuminErythropoietin. |
| spellingShingle | Alsuwaida Abdulkareem Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients Saudi Journal of Kidney Diseases and Transplantation Brain natriuretic peptide Albumin Erythropoietin. |
| title | Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients |
| title_full | Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients |
| title_fullStr | Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients |
| title_full_unstemmed | Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients |
| title_short | Influence of Erythropoietin Dose and Albumin Level on the Plasma Brain Natriuretic Peptide in Hemodialysis Patients |
| title_sort | influence of erythropoietin dose and albumin level on the plasma brain natriuretic peptide in hemodialysis patients |
| topic | Brain natriuretic peptide Albumin Erythropoietin. |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2006;volume=17;issue=2;spage=171;epage=176;aulast=Alsuwaida |
| work_keys_str_mv | AT alsuwaidaabdulkareem influenceoferythropoietindoseandalbuminlevelontheplasmabrainnatriureticpeptideinhemodialysispatients |