Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/6/1/416 |
| _version_ | 1797713676346589184 |
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| author | Sonia Pahwa Maciej J. Stawikowski Gregg B. Fields |
| author_facet | Sonia Pahwa Maciej J. Stawikowski Gregg B. Fields |
| author_sort | Sonia Pahwa |
| collection | DOAJ |
| description | Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors. |
| first_indexed | 2024-03-12T07:40:18Z |
| format | Article |
| id | doaj.art-34359bf153fa4b628bf8e321a98185a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:40:18Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-34359bf153fa4b628bf8e321a98185a82023-09-02T21:18:50ZengMDPI AGCancers2072-66942014-02-016141643510.3390/cancers6010416cancers6010416Monitoring and Inhibiting MT1-MMP during Cancer Initiation and ProgressionSonia Pahwa0Maciej J. Stawikowski1Gregg B. Fields2Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USADepartments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USADepartments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USAMembrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.http://www.mdpi.com/2072-6694/6/1/416MT1-MMPMMP-14matrix metalloproteinasesCD44collagenmetastasis |
| spellingShingle | Sonia Pahwa Maciej J. Stawikowski Gregg B. Fields Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression Cancers MT1-MMP MMP-14 matrix metalloproteinases CD44 collagen metastasis |
| title | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
| title_full | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
| title_fullStr | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
| title_full_unstemmed | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
| title_short | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
| title_sort | monitoring and inhibiting mt1 mmp during cancer initiation and progression |
| topic | MT1-MMP MMP-14 matrix metalloproteinases CD44 collagen metastasis |
| url | http://www.mdpi.com/2072-6694/6/1/416 |
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