Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tu...

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Bibliographic Details
Main Authors: Sonia Pahwa, Maciej J. Stawikowski, Gregg B. Fields
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Cancers
Subjects:
MT1-MMP
MMP-14
matrix metalloproteinases
CD44
collagen
metastasis
Online Access:http://www.mdpi.com/2072-6694/6/1/416

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