Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle
Introduction. The main function of the endometrium is to create the optimal environment for embryo implantation, controlled by multicomponent signaling pathways. They are modulated by progesterone and estradiol acting through related estrogen receptors (ER) and progesterone receptors (PR). Alteratio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2022-07-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/106832/pdf |
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| author | Alina S. Magnaeva Anna V. Tregubova Alexandra A. Tsitrina Alexandra V. Asaturova Marina V. Shamarakova Guzal I. Tabeeva Larisa S. Ezhova Elena A. Kalinina Vladimir K. Bozhenko |
| author_facet | Alina S. Magnaeva Anna V. Tregubova Alexandra A. Tsitrina Alexandra V. Asaturova Marina V. Shamarakova Guzal I. Tabeeva Larisa S. Ezhova Elena A. Kalinina Vladimir K. Bozhenko |
| author_sort | Alina S. Magnaeva |
| collection | DOAJ |
| description | Introduction. The main function of the endometrium is to create the optimal environment for embryo implantation, controlled by multicomponent signaling pathways. They are modulated by progesterone and estradiol acting through related estrogen receptors (ER) and progesterone receptors (PR). Alteration in steroid hormone, follicle-stimulating hormone (FSHR), and luteinizing hormone (LGHR) receptor expression are underlying factors in the development of various reproductive disorders. Therefore, understanding the physiological features of receptors expression and localization in tissues is extremely important for a proper comprehensive assessment of the endometrial condition.
Materials and methods. The expression of ER, PR, FSHR, and LGHR in endometrial samples of healthy females from different menstrual periods, who applied for assisted reproductive technologies (ART) due to male infertility, was assessed by immunofluorescence.
Results. The increase in immunoreactivity of ER, PR, FSHR, and LGHR in the glands and stroma of the endometrium is initiated during the early proliferation stage and reaches its maximum during the late proliferation stage. Subsequently, ER expression in the glands and stroma gradually decreases throughout the early and middle stages of secretion; PR immunoreactivity in the stroma and FSHR and LGHR in all endometrial components persists throughout the secretion stage.
Conclusion. The correspondence between the change of the studied receptors' expression and endometrium structural features at different stages of the menstrual cycle was demonstrated. The increased expression of ER, PR, FSHR, and LGHR in the endometrium at the proliferation stage coincides with the growth period of the uterine body mucosa, and the increased immunoreactivity of PR, FSHR, and LGHR during the secretion stage is associated with its decidual transformation and seems to create conditions for successful implantation and embryo development if pregnancy occurs. |
| first_indexed | 2024-04-13T05:57:37Z |
| format | Article |
| id | doaj.art-3437714d48cf44d995859beb7da5c132 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-04-13T05:57:37Z |
| publishDate | 2022-07-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-3437714d48cf44d995859beb7da5c1322022-12-22T02:59:34ZrusIP Berlin A.V.Гинекология2079-56962079-58312022-07-0124318619210.26442/20795696.2022.3.20167779425Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycleAlina S. Magnaeva0https://orcid.org/0000-0001-5223-9767Anna V. Tregubova1https://orcid.org/0000-0003-4601-1330Alexandra A. Tsitrina2https://orcid.org/0000-0002-2827-9993Alexandra V. Asaturova3https://orcid.org/0000-0001-8739-5209Marina V. Shamarakova4https://orcid.org/0000-0002-0972-4350Guzal I. Tabeeva5https://orcid.org/0000-0003-1498-6520Larisa S. Ezhova6https://orcid.org/0000-0002-9804-8349Elena A. Kalinina7https://orcid.org/0000-0002-8922-2878Vladimir K. Bozhenko8https://orcid.org/0000-0001-8351-8152Kulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKoltzov Institute of Developmental BiologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center for Obstetrics, Gynecology and PerinatologyRussian Scientific Center of RoentgenoradiologyIntroduction. The main function of the endometrium is to create the optimal environment for embryo implantation, controlled by multicomponent signaling pathways. They are modulated by progesterone and estradiol acting through related estrogen receptors (ER) and progesterone receptors (PR). Alteration in steroid hormone, follicle-stimulating hormone (FSHR), and luteinizing hormone (LGHR) receptor expression are underlying factors in the development of various reproductive disorders. Therefore, understanding the physiological features of receptors expression and localization in tissues is extremely important for a proper comprehensive assessment of the endometrial condition. Materials and methods. The expression of ER, PR, FSHR, and LGHR in endometrial samples of healthy females from different menstrual periods, who applied for assisted reproductive technologies (ART) due to male infertility, was assessed by immunofluorescence. Results. The increase in immunoreactivity of ER, PR, FSHR, and LGHR in the glands and stroma of the endometrium is initiated during the early proliferation stage and reaches its maximum during the late proliferation stage. Subsequently, ER expression in the glands and stroma gradually decreases throughout the early and middle stages of secretion; PR immunoreactivity in the stroma and FSHR and LGHR in all endometrial components persists throughout the secretion stage. Conclusion. The correspondence between the change of the studied receptors' expression and endometrium structural features at different stages of the menstrual cycle was demonstrated. The increased expression of ER, PR, FSHR, and LGHR in the endometrium at the proliferation stage coincides with the growth period of the uterine body mucosa, and the increased immunoreactivity of PR, FSHR, and LGHR during the secretion stage is associated with its decidual transformation and seems to create conditions for successful implantation and embryo development if pregnancy occurs.https://gynecology.orscience.ru/2079-5831/article/viewFile/106832/pdfestrogen receptorprogesterone receptorfollicle-stimulating hormone receptorluteinizing hormone receptormenstrual cycle phase |
| spellingShingle | Alina S. Magnaeva Anna V. Tregubova Alexandra A. Tsitrina Alexandra V. Asaturova Marina V. Shamarakova Guzal I. Tabeeva Larisa S. Ezhova Elena A. Kalinina Vladimir K. Bozhenko Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle Гинекология estrogen receptor progesterone receptor follicle-stimulating hormone receptor luteinizing hormone receptor menstrual cycle phase |
| title | Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| title_full | Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| title_fullStr | Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| title_full_unstemmed | Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| title_short | Expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| title_sort | expression of pituitary gonadotropic hormone and sex hormones receptors in endometrial cellular components during menstrual cycle |
| topic | estrogen receptor progesterone receptor follicle-stimulating hormone receptor luteinizing hormone receptor menstrual cycle phase |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/106832/pdf |
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