Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application
The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to imp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1782 |
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| author | Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers |
| author_facet | Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers |
| author_sort | Charis Rousou |
| collection | DOAJ |
| description | The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood–retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed. |
| first_indexed | 2024-03-10T05:08:45Z |
| format | Article |
| id | doaj.art-34378b0abe5948f2ad711c4b85d6fe61 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:08:45Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-34378b0abe5948f2ad711c4b85d6fe612023-11-23T00:57:32ZengMDPI AGPharmaceutics1999-49232021-10-011311178210.3390/pharmaceutics13111782Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical ApplicationCharis Rousou0Carl C. L. Schuurmans1Arto Urtti2Enrico Mastrobattista3Gert Storm4Chrit Moonen5Kai Kaarniranta6Roel Deckers7Departments of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Heidelberglaan 8, 3584 CS Utrecht, The NetherlandsDepartments of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Heidelberglaan 8, 3584 CS Utrecht, The NetherlandsSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70210 Kuopio, FinlandDepartments of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Heidelberglaan 8, 3584 CS Utrecht, The NetherlandsDepartments of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Heidelberglaan 8, 3584 CS Utrecht, The NetherlandsDivision of Imaging and Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Ophthalmology, Kuopio University Hospital, P.O. Box 100, 70029 Kuopio, FinlandDivision of Imaging and Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsThe unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood–retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed.https://www.mdpi.com/1999-4923/13/11/1782ultrasoundmicrobubbledrug deliveryblood–retina barrierocular drug deliveryUSMB |
| spellingShingle | Charis Rousou Carl C. L. Schuurmans Arto Urtti Enrico Mastrobattista Gert Storm Chrit Moonen Kai Kaarniranta Roel Deckers Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application Pharmaceutics ultrasound microbubble drug delivery blood–retina barrier ocular drug delivery USMB |
| title | Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application |
| title_full | Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application |
| title_fullStr | Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application |
| title_full_unstemmed | Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application |
| title_short | Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application |
| title_sort | ultrasound and microbubbles for the treatment of ocular diseases from preclinical research towards clinical application |
| topic | ultrasound microbubble drug delivery blood–retina barrier ocular drug delivery USMB |
| url | https://www.mdpi.com/1999-4923/13/11/1782 |
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