Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study.
<h4>Purpose</h4>To quantitatively assess choriocapillaris (CC) flow deficits in eyes with diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).<h4>Methods</h4>Diabetic subjects with different stages of DR and age-matched healthy subj...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0243830 |
| _version_ | 1818902495378800640 |
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| author | Yining Dai Hao Zhou Qinqin Zhang Zhongdi Chu Lisa C Olmos de Koo Jennifer R Chao Kasra A Rezaei Steven S Saraf Ruikang K Wang |
| author_facet | Yining Dai Hao Zhou Qinqin Zhang Zhongdi Chu Lisa C Olmos de Koo Jennifer R Chao Kasra A Rezaei Steven S Saraf Ruikang K Wang |
| author_sort | Yining Dai |
| collection | DOAJ |
| description | <h4>Purpose</h4>To quantitatively assess choriocapillaris (CC) flow deficits in eyes with diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).<h4>Methods</h4>Diabetic subjects with different stages of DR and age-matched healthy subjects were recruited and imaged with SS-OCTA. The en face CC blood flow images were generated using previously published and validated algorithms. The percentage of CC flow deficits (FD%) and the mean CC flow deficit size were calculated in a 5-mm-diameter circle centered on the fovea from the 6×6-mm scans.<h4>Results</h4>Forty-five diabetic subjects and 27 control subjects were included in the study. The CC FD% in diabetic eyes was on average 1.4-fold greater than in control eyes (12.34±4.14% vs 8.82±2.61%, P < 0.001). The mean CC FD size in diabetic eyes was on average 1.4-fold larger than in control eyes (2151.3± 650.8μm2 vs 1574.4±255.0 μm2, P < 0.001). No significant difference in CC FD% or mean CC FD size was observed between eyes with nonproliferative DR and eyes with proliferative DR (P = 1.000 and P = 1.000, respectively).<h4>Conclusions</h4>CC perfusion in DR can be objectively and quantitatively assessed with FD% and FD size. In the macular region, both CC FD% and CC FD size are increased in eyes with DR. SS-OCTA provides new insights for the investigations of CC perfusion status in diabetes in vivo. |
| first_indexed | 2024-12-19T20:36:33Z |
| format | Article |
| id | doaj.art-343828354d40436a94d24e93ed5fef7e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T20:36:33Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-343828354d40436a94d24e93ed5fef7e2022-12-21T20:06:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024383010.1371/journal.pone.0243830Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study.Yining DaiHao ZhouQinqin ZhangZhongdi ChuLisa C Olmos de KooJennifer R ChaoKasra A RezaeiSteven S SarafRuikang K Wang<h4>Purpose</h4>To quantitatively assess choriocapillaris (CC) flow deficits in eyes with diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).<h4>Methods</h4>Diabetic subjects with different stages of DR and age-matched healthy subjects were recruited and imaged with SS-OCTA. The en face CC blood flow images were generated using previously published and validated algorithms. The percentage of CC flow deficits (FD%) and the mean CC flow deficit size were calculated in a 5-mm-diameter circle centered on the fovea from the 6×6-mm scans.<h4>Results</h4>Forty-five diabetic subjects and 27 control subjects were included in the study. The CC FD% in diabetic eyes was on average 1.4-fold greater than in control eyes (12.34±4.14% vs 8.82±2.61%, P < 0.001). The mean CC FD size in diabetic eyes was on average 1.4-fold larger than in control eyes (2151.3± 650.8μm2 vs 1574.4±255.0 μm2, P < 0.001). No significant difference in CC FD% or mean CC FD size was observed between eyes with nonproliferative DR and eyes with proliferative DR (P = 1.000 and P = 1.000, respectively).<h4>Conclusions</h4>CC perfusion in DR can be objectively and quantitatively assessed with FD% and FD size. In the macular region, both CC FD% and CC FD size are increased in eyes with DR. SS-OCTA provides new insights for the investigations of CC perfusion status in diabetes in vivo.https://doi.org/10.1371/journal.pone.0243830 |
| spellingShingle | Yining Dai Hao Zhou Qinqin Zhang Zhongdi Chu Lisa C Olmos de Koo Jennifer R Chao Kasra A Rezaei Steven S Saraf Ruikang K Wang Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. PLoS ONE |
| title | Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. |
| title_full | Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. |
| title_fullStr | Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. |
| title_full_unstemmed | Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. |
| title_short | Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study. |
| title_sort | quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy a swept source optical coherence tomography angiography study |
| url | https://doi.org/10.1371/journal.pone.0243830 |
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