Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis
The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/4/1044 |
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| author | Venkatesh Mayandi Wen-Tyng Kang Darren Shu Jeng Ting Eunice Tze Leng Goh Myoe Naing Lynn Thet Tun Aung Jamuna Vadivelu Veluchamy Amutha Barathi Anita Sook Yee Chan Rajamani Lakshminarayanan |
| author_facet | Venkatesh Mayandi Wen-Tyng Kang Darren Shu Jeng Ting Eunice Tze Leng Goh Myoe Naing Lynn Thet Tun Aung Jamuna Vadivelu Veluchamy Amutha Barathi Anita Sook Yee Chan Rajamani Lakshminarayanan |
| author_sort | Venkatesh Mayandi |
| collection | DOAJ |
| description | The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise that propranolol is known to inhibit fungal hyphae. In vitro studies demonstrate that propranolol potentiates the antifungal activity of azoles and that the effect is more pronounced for propranolol–itraconazole combination. Using an in vivo murine systemic candidemia model, we show that propranolol–itraconazole combination treatment resulted in a lower rate of body weight loss, decreased kidney fungal bioburden and renal inflammation when compared to propranolol and azole treatment alone or untreated control. Altogether, our findings suggest that propranolol increases the efficacy of azoles against <i>C. albicans</i>, offering a new therapeutic strategy against invasive fungal infections. |
| first_indexed | 2024-03-11T04:38:04Z |
| format | Article |
| id | doaj.art-343ac341d3614defaaa57811714693e2 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:38:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-343ac341d3614defaaa57811714693e22023-11-17T20:51:55ZengMDPI AGPharmaceutics1999-49232023-03-01154104410.3390/pharmaceutics15041044Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive CandidiasisVenkatesh Mayandi0Wen-Tyng Kang1Darren Shu Jeng Ting2Eunice Tze Leng Goh3Myoe Naing Lynn4Thet Tun Aung5Jamuna Vadivelu6Veluchamy Amutha Barathi7Anita Sook Yee Chan8Rajamani Lakshminarayanan9Ocular Infections and Anti-Microbials Research, Singapore Eye Research Institute, Singapore 169856, SingaporeDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, MalaysiaOcular Infections and Anti-Microbials Research, Singapore Eye Research Institute, Singapore 169856, SingaporeOcular Infections and Anti-Microbials Research, Singapore Eye Research Institute, Singapore 169856, SingaporeTranslational Ophthalmic Pathology-Immunology Platform, Singapore Eye Research Institute, Singapore 169856, SingaporeOcular Infections and Anti-Microbials Research, Singapore Eye Research Institute, Singapore 169856, SingaporeDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, MalaysiaOphthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore 169857, SingaporeOphthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore 169857, SingaporeOcular Infections and Anti-Microbials Research, Singapore Eye Research Institute, Singapore 169856, SingaporeThe effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise that propranolol is known to inhibit fungal hyphae. In vitro studies demonstrate that propranolol potentiates the antifungal activity of azoles and that the effect is more pronounced for propranolol–itraconazole combination. Using an in vivo murine systemic candidemia model, we show that propranolol–itraconazole combination treatment resulted in a lower rate of body weight loss, decreased kidney fungal bioburden and renal inflammation when compared to propranolol and azole treatment alone or untreated control. Altogether, our findings suggest that propranolol increases the efficacy of azoles against <i>C. albicans</i>, offering a new therapeutic strategy against invasive fungal infections.https://www.mdpi.com/1999-4923/15/4/1044antifungal therapiessynergismpropranolol–itraconazole<i>Candida albicans</i> |
| spellingShingle | Venkatesh Mayandi Wen-Tyng Kang Darren Shu Jeng Ting Eunice Tze Leng Goh Myoe Naing Lynn Thet Tun Aung Jamuna Vadivelu Veluchamy Amutha Barathi Anita Sook Yee Chan Rajamani Lakshminarayanan Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis Pharmaceutics antifungal therapies synergism propranolol–itraconazole <i>Candida albicans</i> |
| title | Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis |
| title_full | Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis |
| title_fullStr | Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis |
| title_full_unstemmed | Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis |
| title_short | Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis |
| title_sort | propranolol ameliorates the antifungal activity of azoles in invasive candidiasis |
| topic | antifungal therapies synergism propranolol–itraconazole <i>Candida albicans</i> |
| url | https://www.mdpi.com/1999-4923/15/4/1044 |
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