Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission
Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021007234 |
| _version_ | 1819140458790518784 |
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| author | Wcleubianne Matias Nascimento Maia Francisco Das Chagas Pereira de Andrade Livia Alves Filgueiras Anderson Nogueira Mendes Amanda Fonseca Costa Assunção Nicolas Davidson Sérvulo Rodrigues Rosemarie Brandim Marques Antônio Luiz Martins Maia Filho Damião Pergentino de Sousa Luciano Da Silva Lopes |
| author_facet | Wcleubianne Matias Nascimento Maia Francisco Das Chagas Pereira de Andrade Livia Alves Filgueiras Anderson Nogueira Mendes Amanda Fonseca Costa Assunção Nicolas Davidson Sérvulo Rodrigues Rosemarie Brandim Marques Antônio Luiz Martins Maia Filho Damião Pergentino de Sousa Luciano Da Silva Lopes |
| author_sort | Wcleubianne Matias Nascimento Maia |
| collection | DOAJ |
| description | Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of action. Analysis of ADMET pharmacokinetic properties (absorption, distribution, metabolism, excretion and toxicity) of rose oxide was performed by computational prediction analysis. Behavioral tests were performed to assess the interaction between rose oxide and the central nervous system and antidepressant effect that includes: forced swim test (FST), tail suspension test (TST), open field test (OFT) and rota-rod test. The results of pharmacokinetic and toxicological properties indicate that rose oxide could be used orally, since it has good intestinal absorption as well as pharmacological and toxicological properties that can be similar to pharmacological compounds (regular hepatic metabolism and low toxicity). Treatment with 50 mg/kg of rose oxide was able to decrease the immobility time of animals not affected by FST and TST and was not able to alter the motor activity of the OFT and rota-rod test, suggesting modulation and antidepressant activity. Docking data suggest that rose oxide can bind to receptors in the serotonergic pathway. The results described here suggest that rose oxide has antidepressant activity, modulating the serotonergic pathway. |
| first_indexed | 2024-12-22T11:38:53Z |
| format | Article |
| id | doaj.art-343b847f9ced4fafb5720338944228ea |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-22T11:38:53Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-343b847f9ced4fafb5720338944228ea2022-12-21T18:27:20ZengElsevierHeliyon2405-84402021-04-0174e06620Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmissionWcleubianne Matias Nascimento Maia0Francisco Das Chagas Pereira de Andrade1Livia Alves Filgueiras2Anderson Nogueira Mendes3Amanda Fonseca Costa Assunção4Nicolas Davidson Sérvulo Rodrigues5Rosemarie Brandim Marques6Antônio Luiz Martins Maia Filho7Damião Pergentino de Sousa8Luciano Da Silva Lopes9Postgraduate Programs in Pharmaceutical Sciences and Laboratory of Research in Experimental Neurochemistry (LAPNEX), Federal University of Piauí, 64049-550, Teresina, BrazilLaboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, BrazilLaboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, BrazilLaboratory of Innovation in Science and Technology, LACITEC, Department of Biophysics and Physiology, Federal University of Piauí, 64049-550, Teresina, Piauí, BrazilNucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, BrazilNucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, BrazilNucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, BrazilNucleus of Biotechnology and Biodiversity of the State University of Piauí, 64003-120, Teresina, Piauí, BrazilDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, PB, BrazilPostgraduate Programs in Pharmaceutical Sciences and Laboratory of Research in Experimental Neurochemistry (LAPNEX), Federal University of Piauí, 64049-550, Teresina, Brazil; Corresponding author.Rose oxide (RO) is a monoterpene found in rose oil fragrances. This monoterpene has been reported to possess anti-inflammatory activity, however, little is known regarding its pharmacological activity. The present study was carried out to evaluate its antidepressant action and possible mechanisms of action. Analysis of ADMET pharmacokinetic properties (absorption, distribution, metabolism, excretion and toxicity) of rose oxide was performed by computational prediction analysis. Behavioral tests were performed to assess the interaction between rose oxide and the central nervous system and antidepressant effect that includes: forced swim test (FST), tail suspension test (TST), open field test (OFT) and rota-rod test. The results of pharmacokinetic and toxicological properties indicate that rose oxide could be used orally, since it has good intestinal absorption as well as pharmacological and toxicological properties that can be similar to pharmacological compounds (regular hepatic metabolism and low toxicity). Treatment with 50 mg/kg of rose oxide was able to decrease the immobility time of animals not affected by FST and TST and was not able to alter the motor activity of the OFT and rota-rod test, suggesting modulation and antidepressant activity. Docking data suggest that rose oxide can bind to receptors in the serotonergic pathway. The results described here suggest that rose oxide has antidepressant activity, modulating the serotonergic pathway.http://www.sciencedirect.com/science/article/pii/S2405844021007234DepressionOxide roseSerotonergic pathwayADMET |
| spellingShingle | Wcleubianne Matias Nascimento Maia Francisco Das Chagas Pereira de Andrade Livia Alves Filgueiras Anderson Nogueira Mendes Amanda Fonseca Costa Assunção Nicolas Davidson Sérvulo Rodrigues Rosemarie Brandim Marques Antônio Luiz Martins Maia Filho Damião Pergentino de Sousa Luciano Da Silva Lopes Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission Heliyon Depression Oxide rose Serotonergic pathway ADMET |
| title | Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission |
| title_full | Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission |
| title_fullStr | Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission |
| title_full_unstemmed | Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission |
| title_short | Antidepressant activity of rose oxide essential oil: possible involvement of serotonergic transmission |
| title_sort | antidepressant activity of rose oxide essential oil possible involvement of serotonergic transmission |
| topic | Depression Oxide rose Serotonergic pathway ADMET |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021007234 |
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