T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV
Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effectiv...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622000886 |
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| author | Dionna W. Williams Bianca R. Flores Yanxun Xu Yuezhe Wang Danyang Yu Brandilyn A. Peters Adebola Adedimeji Tracey E. Wilson Daniel Merenstein Phyllis C. Tien Mardge H. Cohen Kathleen M. Weber Adaora A. Adimora Igho Ofotokun Margaret Fischl Janet Turan Bülent Turan Geoffroy Laumet Alan L. Landay Raha M. Dastgheyb Stephen J. Gange Sheri D. Weiser Leah H. Rubin |
| author_facet | Dionna W. Williams Bianca R. Flores Yanxun Xu Yuezhe Wang Danyang Yu Brandilyn A. Peters Adebola Adedimeji Tracey E. Wilson Daniel Merenstein Phyllis C. Tien Mardge H. Cohen Kathleen M. Weber Adaora A. Adimora Igho Ofotokun Margaret Fischl Janet Turan Bülent Turan Geoffroy Laumet Alan L. Landay Raha M. Dastgheyb Stephen J. Gange Sheri D. Weiser Leah H. Rubin |
| author_sort | Dionna W. Williams |
| collection | DOAJ |
| description | Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/<20cp/mL) enrolled in the Women's Interagency HIV Study completed neuropsychological testing and measures of depression (Center for Epidemiological Studies Depression Scale-CES-D), self-reported stress levels (Perceived Stress Scale-10), and post-traumatic stress (PTSD Checklist-Civilian Scale). Multiparametric flow cytometry evaluated T-cell activation state. Partial least squares regressions were used to examine T-cell phenotypes and neuropsychiatric outcome associations after confounder adjustment. In the total sample and among virally suppressed (VS)-WWH, CD4+ T-cell exhaustion was associated with poorer learning and attention/working memory (P's < 0.05). In the total sample, CD4+ T-cell activation was associated with better attention/working memory and CD8+ T-cell co-stimulation and senescence was associated with poorer executive function (P's < 0.05). For mental health outcomes, in the total sample, CD4+ T-cell activation was associated with more perceived stress and CD4+ T-cell exhaustion was associated with less depressive symptoms (P's < 0.05). Among VS-WWH, CD4+ senescence was associated with less perceive stress and CD8+ T-cell co-stimulation and senescence was associated with higher depression (P's < 0.05). Together, results suggest the contribution of peripheral CD4+ and CD8+ T-cell activation status to neuropsychiatric complications in WWH. |
| first_indexed | 2024-04-12T17:13:51Z |
| format | Article |
| id | doaj.art-343c52777eb14015a1b0466b4d2aeebd |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-12T17:13:51Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-343c52777eb14015a1b0466b4d2aeebd2022-12-22T03:23:42ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-11-0125100498T-cell activation state differentially contributes to neuropsychiatric complications in women with HIVDionna W. Williams0Bianca R. Flores1Yanxun Xu2Yuezhe Wang3Danyang Yu4Brandilyn A. Peters5Adebola Adedimeji6Tracey E. Wilson7Daniel Merenstein8Phyllis C. Tien9Mardge H. Cohen10Kathleen M. Weber11Adaora A. Adimora12Igho Ofotokun13Margaret Fischl14Janet Turan15Bülent Turan16Geoffroy Laumet17Alan L. Landay18Raha M. Dastgheyb19Stephen J. Gange20Sheri D. Weiser21Leah H. Rubin22Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAApplied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA; Division of Biostatistics and Bioinformatics at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USAApplied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USAApplied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USADepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Community Health Sciences, State University of New York Downstate Health Science University, School of Public Health, Brooklyn, NY, USADepartment of Family Medicine, Georgetown University Medical Center, Washington, DC, USADepartment of Medicine, UCSF and Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA, USADepartment of Medicine, Stroger Hospital, Chicago, IL, USACook County Health/Hektoen Institute of Medicine, Chicago, IL, USADivision of Infectious Disease, University of North Carolina at Chapel Hill, NC, USADepartment of Medicine, Emory University and Grady Healthcare System, Atlanta, Georgia Mailman School of Public Health, Columbia University, NY, NY, USADepartment of Medicine, University of Miami Health System, Miami, FL, USADepartments of Health Policy and Organization, School of Public Health, University of Alabama at Birmingham, USADepartment of Psychology, Koc University, Istanbul, TurkeyDepartment of Physiology, Michigan State University, East Lansing, MI, USADepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, USADepartments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USADepartment of Medicine, UCSF and Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA, USA; Division of HIV, ID and Global Medicine, Department of Medicine, UCSF, San Francisco, CA, USADepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Corresponding author. Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/ Meyer 6-113, Baltimore, MD, 21287-7613, USA.Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/<20cp/mL) enrolled in the Women's Interagency HIV Study completed neuropsychological testing and measures of depression (Center for Epidemiological Studies Depression Scale-CES-D), self-reported stress levels (Perceived Stress Scale-10), and post-traumatic stress (PTSD Checklist-Civilian Scale). Multiparametric flow cytometry evaluated T-cell activation state. Partial least squares regressions were used to examine T-cell phenotypes and neuropsychiatric outcome associations after confounder adjustment. In the total sample and among virally suppressed (VS)-WWH, CD4+ T-cell exhaustion was associated with poorer learning and attention/working memory (P's < 0.05). In the total sample, CD4+ T-cell activation was associated with better attention/working memory and CD8+ T-cell co-stimulation and senescence was associated with poorer executive function (P's < 0.05). For mental health outcomes, in the total sample, CD4+ T-cell activation was associated with more perceived stress and CD4+ T-cell exhaustion was associated with less depressive symptoms (P's < 0.05). Among VS-WWH, CD4+ senescence was associated with less perceive stress and CD8+ T-cell co-stimulation and senescence was associated with higher depression (P's < 0.05). Together, results suggest the contribution of peripheral CD4+ and CD8+ T-cell activation status to neuropsychiatric complications in WWH.http://www.sciencedirect.com/science/article/pii/S2666354622000886HIVT-cell functionCognitionMental healthWomen |
| spellingShingle | Dionna W. Williams Bianca R. Flores Yanxun Xu Yuezhe Wang Danyang Yu Brandilyn A. Peters Adebola Adedimeji Tracey E. Wilson Daniel Merenstein Phyllis C. Tien Mardge H. Cohen Kathleen M. Weber Adaora A. Adimora Igho Ofotokun Margaret Fischl Janet Turan Bülent Turan Geoffroy Laumet Alan L. Landay Raha M. Dastgheyb Stephen J. Gange Sheri D. Weiser Leah H. Rubin T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV Brain, Behavior, & Immunity - Health HIV T-cell function Cognition Mental health Women |
| title | T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV |
| title_full | T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV |
| title_fullStr | T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV |
| title_full_unstemmed | T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV |
| title_short | T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV |
| title_sort | t cell activation state differentially contributes to neuropsychiatric complications in women with hiv |
| topic | HIV T-cell function Cognition Mental health Women |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622000886 |
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