Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion

PurposeRetinal vein occlusion (RVO) is a sight-threatening condition typically treated with intravitreal injection of vascular endothelial growth factor (VEGF) antagonists. Treatment response to anti-VEGF therapies is highly variable, with poor visual outcomes and treatment response in patients with...

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Bibliographic Details
Main Authors: Maria I. Avrutsky, Claire W. Chen, Jacqueline M. Lawson, Scott J. Snipas, Guy S. Salvesen, Carol M. Troy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
retinal vein occlusion
VEGF
caspase-9
cell penetrating peptide
neurodegeneration
neurovascular
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1209527/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1209527/full

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