Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study
Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial–ankle pulse wave velocity (baPWV). This population-base...
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MDPI AG
2021-12-01
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author | Kyi Mar Wai Sawada Kaori Ken Itoh Okuyama Shinya Yuka Uchikawa Sakura Hayashi Akiko Shiraki Koichi Murashita Shigeyuki Nakaji Kazushige Ihara |
author_facet | Kyi Mar Wai Sawada Kaori Ken Itoh Okuyama Shinya Yuka Uchikawa Sakura Hayashi Akiko Shiraki Koichi Murashita Shigeyuki Nakaji Kazushige Ihara |
author_sort | Kyi Mar Wai |
collection | DOAJ |
description | Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial–ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: −41.24, 95% confidence interval (CI): −76.81, −5.68). The mean baPWV decreased with a longer TL (TL G-tail length: <i>p</i> trend < 0.001, total TL: <i>p</i> trend < 0.001). TL G-tail and total TL lengths were inversely associated with baPWV, implicating TL shortening in the development of CVD. This study provides evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome. |
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issn | 2075-4426 |
language | English |
last_indexed | 2024-03-10T03:46:38Z |
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spelling | doaj.art-343e8525545e499dbcd1647f857e1ead2023-11-23T09:07:18ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112127810.3390/jpm11121278Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional StudyKyi Mar Wai0Sawada Kaori1Ken Itoh2Okuyama Shinya3Yuka Uchikawa4Sakura Hayashi5Akiko Shiraki6Koichi Murashita7Shigeyuki Nakaji8Kazushige Ihara9Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanCenter of Advanced Medical Science, Department of Stress Response Science, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanResearch and Development Division, MiRTeL Company Limited, Hiroshima 734-0001, JapanBusiness Development Division, MiRTeL Company Limited, Hiroshima 734-0001, JapanInspection Division, MiRTeL Company Limited, Hiroshima 734-0001, JapanCenter of Innovation, Research Initiatives Organization, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanDepartment of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, JapanTelomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial–ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: −41.24, 95% confidence interval (CI): −76.81, −5.68). The mean baPWV decreased with a longer TL (TL G-tail length: <i>p</i> trend < 0.001, total TL: <i>p</i> trend < 0.001). TL G-tail and total TL lengths were inversely associated with baPWV, implicating TL shortening in the development of CVD. This study provides evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome.https://www.mdpi.com/2075-4426/11/12/1278telomereG-tail lengthpulse wave velocityarterial stiffnessJapan |
spellingShingle | Kyi Mar Wai Sawada Kaori Ken Itoh Okuyama Shinya Yuka Uchikawa Sakura Hayashi Akiko Shiraki Koichi Murashita Shigeyuki Nakaji Kazushige Ihara Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study Journal of Personalized Medicine telomere G-tail length pulse wave velocity arterial stiffness Japan |
title | Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study |
title_full | Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study |
title_fullStr | Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study |
title_full_unstemmed | Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study |
title_short | Telomere Length and Arterial Stiffness Reflected by Brachial–Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study |
title_sort | telomere length and arterial stiffness reflected by brachial ankle pulse wave velocity a population based cross sectional study |
topic | telomere G-tail length pulse wave velocity arterial stiffness Japan |
url | https://www.mdpi.com/2075-4426/11/12/1278 |
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