Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China
Background and study aims The aim of the study was to evaluate short- and long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in China because no study has yet been conducted to confirm its effectiveness in EGC in China. Patients and methods A total...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2021-06-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1381-7013 |
| _version_ | 1819079543729684480 |
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| author | Qing-Wei Zhang Jin-Nan Chen Zhao-Rong Tang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li |
| author_facet | Qing-Wei Zhang Jin-Nan Chen Zhao-Rong Tang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li |
| author_sort | Qing-Wei Zhang |
| collection | DOAJ |
| description | Background and study aims The aim of the study was to evaluate short- and long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in China because no study has yet been conducted to confirm its effectiveness in EGC in China.
Patients and methods A total of 570 EGC samples from 537 patients were collected for evaluation of en bloc, complete, and curative resection using ESD. Data from 302 patients with at least 3 years of active follow-up were collected for analysis of recurrence of EGC and occurrence of metachronous GC (MGC). Short- and long-outcomes of mixed-type and pure differentiated EGC were also compared.
Results En bloc resection rates of 96.0 %, 98.7 %, and 95.2 %, complete resection rates of 91.2 %, 96.6 % and 90.8 %, and curative resection rates of 83.0 %, 96.2 % and 88.2 % were achieved in all EGCs included in the study, those with absolute indication, and those with expanded indication, respectively. As a long-term outcome, recurrence was observed in 1.3 % of patients, 3-year and 5-year recurrence rates being 0.7 % and 1.2 %, respectively. Thirteen patients (4.3 %) exhibited MGCs during follow-up, all of which were resected in a second ESD.
Conclusions The effectiveness of ESD for EGC in China was confirmed, with satisfactory short- and long-term outcomes. With scheduled follow-up, the outcomes for mixed-type EGC can be similar to those for pure differentiated EGC after complete resection without development of lymphovascular invasion. |
| first_indexed | 2024-12-21T19:30:40Z |
| format | Article |
| id | doaj.art-343f7626cfce4435acfa800d6928b601 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-21T19:30:40Z |
| publishDate | 2021-06-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-343f7626cfce4435acfa800d6928b6012022-12-21T18:52:42ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362021-06-010907E1086E109610.1055/a-1381-7013Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from ChinaQing-Wei Zhang0Jin-Nan Chen1Zhao-Rong Tang2Yun-Jie Gao3Zhi-Zheng Ge4Xiao-Bo Li5Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, ChinaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, ChinaDepartment of Gastroenterology and Hepatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, ChinaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, ChinaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, ChinaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, ChinaBackground and study aims The aim of the study was to evaluate short- and long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in China because no study has yet been conducted to confirm its effectiveness in EGC in China. Patients and methods A total of 570 EGC samples from 537 patients were collected for evaluation of en bloc, complete, and curative resection using ESD. Data from 302 patients with at least 3 years of active follow-up were collected for analysis of recurrence of EGC and occurrence of metachronous GC (MGC). Short- and long-outcomes of mixed-type and pure differentiated EGC were also compared. Results En bloc resection rates of 96.0 %, 98.7 %, and 95.2 %, complete resection rates of 91.2 %, 96.6 % and 90.8 %, and curative resection rates of 83.0 %, 96.2 % and 88.2 % were achieved in all EGCs included in the study, those with absolute indication, and those with expanded indication, respectively. As a long-term outcome, recurrence was observed in 1.3 % of patients, 3-year and 5-year recurrence rates being 0.7 % and 1.2 %, respectively. Thirteen patients (4.3 %) exhibited MGCs during follow-up, all of which were resected in a second ESD. Conclusions The effectiveness of ESD for EGC in China was confirmed, with satisfactory short- and long-term outcomes. With scheduled follow-up, the outcomes for mixed-type EGC can be similar to those for pure differentiated EGC after complete resection without development of lymphovascular invasion.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1381-7013 |
| spellingShingle | Qing-Wei Zhang Jin-Nan Chen Zhao-Rong Tang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China Endoscopy International Open |
| title | Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China |
| title_full | Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China |
| title_fullStr | Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China |
| title_full_unstemmed | Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China |
| title_short | Long- and short-term outcomes of early gastric cancer after endoscopic resection: a retrospective study from China |
| title_sort | long and short term outcomes of early gastric cancer after endoscopic resection a retrospective study from china |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1381-7013 |
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