Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment

Colorectal cancer (CRC) is one of the most common tumors worldwide, with a higher rate of distant metastases than other malignancies and with regular occurrence of drug resistance. Therefore, scientists are forced to further develop novel and innovative therapeutic treatment strategies, whereby it h...

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Main Authors: Anna-Lena Mueller, Aranka Brockmueller, Niusha Fahimi, Tahere Ghotbi, Sara Hashemi, Sadaf Sadri, Negar Khorshidi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/10/4/832
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author Anna-Lena Mueller
Aranka Brockmueller
Niusha Fahimi
Tahere Ghotbi
Sara Hashemi
Sadaf Sadri
Negar Khorshidi
Ajaikumar B. Kunnumakkara
Mehdi Shakibaei
author_facet Anna-Lena Mueller
Aranka Brockmueller
Niusha Fahimi
Tahere Ghotbi
Sara Hashemi
Sadaf Sadri
Negar Khorshidi
Ajaikumar B. Kunnumakkara
Mehdi Shakibaei
author_sort Anna-Lena Mueller
collection DOAJ
description Colorectal cancer (CRC) is one of the most common tumors worldwide, with a higher rate of distant metastases than other malignancies and with regular occurrence of drug resistance. Therefore, scientists are forced to further develop novel and innovative therapeutic treatment strategies, whereby it has been discovered microorganisms, albeit linked to CRC pathogenesis, are able to act as highly selective CRC treatment agents. Consequently, researchers are increasingly focusing on bacteriotherapy as a novel therapeutic strategy with less or no side effects compared to standard cancer treatment methods. With multiple successful trials making use of various bacteria-associated mechanisms, bacteriotherapy in cancer treatment is on its way to become a promising tool in CRC targeting therapy. In this study, we describe the anti-cancer effects of bacterial therapy focusing on the treatment of CRC as well as diverse modulatory mechanisms and techniques that bacteriotherapy offers such as bacterial-related biotherapeutics including peptides, toxins, bacteriocins or the use of bacterial carriers and underlying molecular processes to target colorectal tumors.
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spelling doaj.art-34406087bb4749c39bd21bc40fe4f3c32023-12-01T00:54:01ZengMDPI AGBiomedicines2227-90592022-04-0110483210.3390/biomedicines10040832Bacteria-Mediated Modulatory Strategies for Colorectal Cancer TreatmentAnna-Lena Mueller0Aranka Brockmueller1Niusha Fahimi2Tahere Ghotbi3Sara Hashemi4Sadaf Sadri5Negar Khorshidi6Ajaikumar B. Kunnumakkara7Mehdi Shakibaei8Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, 80336 Munich, GermanyMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, 80336 Munich, GermanyFaculty of Pharmacy, Comenius University, 83232 Bratislava, SlovakiaDepartment of Nursing, Shiraz University of Medical Sciences, Shiraz 7134814336, IranCentral Tehran Branch, Islamic Azad University, Tehran 1955847881, IranDepartment of Microbiology, University of Mazandaran, Babolsar 4741613534, IranDepartment of Medicinal Chemistry, Medical Sciences Branch, Islamic Azad University, Tehran 1913674711, IranCancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati 781039, IndiaMusculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, 80336 Munich, GermanyColorectal cancer (CRC) is one of the most common tumors worldwide, with a higher rate of distant metastases than other malignancies and with regular occurrence of drug resistance. Therefore, scientists are forced to further develop novel and innovative therapeutic treatment strategies, whereby it has been discovered microorganisms, albeit linked to CRC pathogenesis, are able to act as highly selective CRC treatment agents. Consequently, researchers are increasingly focusing on bacteriotherapy as a novel therapeutic strategy with less or no side effects compared to standard cancer treatment methods. With multiple successful trials making use of various bacteria-associated mechanisms, bacteriotherapy in cancer treatment is on its way to become a promising tool in CRC targeting therapy. In this study, we describe the anti-cancer effects of bacterial therapy focusing on the treatment of CRC as well as diverse modulatory mechanisms and techniques that bacteriotherapy offers such as bacterial-related biotherapeutics including peptides, toxins, bacteriocins or the use of bacterial carriers and underlying molecular processes to target colorectal tumors.https://www.mdpi.com/2227-9059/10/4/832colorectal cancerbiotherapeutical toxinsbacteriocinsbacterial peptidesbacteriotherapymicrobiota
spellingShingle Anna-Lena Mueller
Aranka Brockmueller
Niusha Fahimi
Tahere Ghotbi
Sara Hashemi
Sadaf Sadri
Negar Khorshidi
Ajaikumar B. Kunnumakkara
Mehdi Shakibaei
Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
Biomedicines
colorectal cancer
biotherapeutical toxins
bacteriocins
bacterial peptides
bacteriotherapy
microbiota
title Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
title_full Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
title_fullStr Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
title_full_unstemmed Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
title_short Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
title_sort bacteria mediated modulatory strategies for colorectal cancer treatment
topic colorectal cancer
biotherapeutical toxins
bacteriocins
bacterial peptides
bacteriotherapy
microbiota
url https://www.mdpi.com/2227-9059/10/4/832
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