Sepsis – it is all about the platelets
Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause se...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210219/full |
| _version_ | 1797809768526512128 |
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| author | Dermot Cox |
| author_facet | Dermot Cox |
| author_sort | Dermot Cox |
| collection | DOAJ |
| description | Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis. |
| first_indexed | 2024-03-13T06:58:46Z |
| format | Article |
| id | doaj.art-34406ef52b8f432990af713c43daf040 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T06:58:46Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-34406ef52b8f432990af713c43daf0402023-06-07T04:49:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.12102191210219Sepsis – it is all about the plateletsDermot CoxSepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210219/fullplateletssepsisinnate immunitythrombosisanti-platelet agents |
| spellingShingle | Dermot Cox Sepsis – it is all about the platelets Frontiers in Immunology platelets sepsis innate immunity thrombosis anti-platelet agents |
| title | Sepsis – it is all about the platelets |
| title_full | Sepsis – it is all about the platelets |
| title_fullStr | Sepsis – it is all about the platelets |
| title_full_unstemmed | Sepsis – it is all about the platelets |
| title_short | Sepsis – it is all about the platelets |
| title_sort | sepsis it is all about the platelets |
| topic | platelets sepsis innate immunity thrombosis anti-platelet agents |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1210219/full |
| work_keys_str_mv | AT dermotcox sepsisitisallabouttheplatelets |