Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method
Abstract Background Medial compartment knee osteoarthritis (KOA) accounts for most KOA cases, and increased trabecular bone volume fraction (BV/TV) is one of the pathological changes in the tibial plateau of KOA. How BV/TV changes before and after the menopause and its effects on medial compartment...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-022-01039-x |
| _version_ | 1798000636412821504 |
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| author | Liqin Zheng Yuexing Dai Yongze Zheng Xingpeng He Minhui Wu Desheng Zheng ChiHung Li Yueguang Fan Ziling Lin |
| author_facet | Liqin Zheng Yuexing Dai Yongze Zheng Xingpeng He Minhui Wu Desheng Zheng ChiHung Li Yueguang Fan Ziling Lin |
| author_sort | Liqin Zheng |
| collection | DOAJ |
| description | Abstract Background Medial compartment knee osteoarthritis (KOA) accounts for most KOA cases, and increased trabecular bone volume fraction (BV/TV) is one of the pathological changes in the tibial plateau of KOA. How BV/TV changes before and after the menopause and its effects on medial compartment KOA are yet to be clarified. Methods Twenty femurs from twenty 12-week-old rats were included. The operated group underwent ovariectomy (to represent the osteoporosis condition), called the O group, and the non-operated group was the normal control, called the N group. Micro-CT scans of the femoral condyles were acquired 12 weeks after the surgery, and the volume of interest (VOI) of medial-, inter-, and lateral-condyle trabeculae were three-dimensional (3D) printed for uniaxial compression mechanical test and simulated by the finite element (FE) method. Results The results demonstrated that the O group indicated poorer trabecular architecture than the N group in three parts of the femoral condyle, especially in the intercondyle. Within the group, the BV/TV, trabecular thickness (Tb.Th), and trabecular number (Tb.N) ratios between the medial and lateral condyles were greater than 1 in both N and O groups. The medial condyle trabeculae's mechanical properties were higher than those of the lateral condyle, and this superiority appears to be broadened under osteoporotic conditions. FE modelling well reproduced these mechanical differentiations. Conclusions According to Wolff's law, the higher BV/TV and mechanical properties of the medial femoral condyle may be due to inherent imbalanced loading on the knee component. Alterations in BV/TV and their corresponding mechanical properties may accompany KOA. |
| first_indexed | 2024-04-11T11:23:29Z |
| format | Article |
| id | doaj.art-344071c05de9488a859da2fedb3085e2 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-04-11T11:23:29Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-344071c05de9488a859da2fedb3085e22022-12-22T04:26:22ZengBMCBioMedical Engineering OnLine1475-925X2022-09-0121111810.1186/s12938-022-01039-xMedial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element methodLiqin Zheng0Yuexing Dai1Yongze Zheng2Xingpeng He3Minhui Wu4Desheng Zheng5ChiHung Li6Yueguang Fan7Ziling Lin8The First Clinical Medical College, Guangzhou University of Chinese MedicineThe First Clinical Medical College, Guangzhou University of Chinese MedicineDepartment of Orthopedics, Puning Hospital of Traditional Chinese MedicineThe First Clinical Medical College, Guangzhou University of Chinese MedicineThe First Clinical Medical College, Guangzhou University of Chinese MedicineThe First Clinical Medical College, Guangzhou University of Chinese MedicineInternational College, Guangzhou University of Chinese MedicineDepartment of Joint Surgery, First Affiliated Hospital of Guangzhou University of Chinese MedicineDepartment of Orthopedic Trauma, First Affiliated Hospital of Guangzhou University of Chinese MedicineAbstract Background Medial compartment knee osteoarthritis (KOA) accounts for most KOA cases, and increased trabecular bone volume fraction (BV/TV) is one of the pathological changes in the tibial plateau of KOA. How BV/TV changes before and after the menopause and its effects on medial compartment KOA are yet to be clarified. Methods Twenty femurs from twenty 12-week-old rats were included. The operated group underwent ovariectomy (to represent the osteoporosis condition), called the O group, and the non-operated group was the normal control, called the N group. Micro-CT scans of the femoral condyles were acquired 12 weeks after the surgery, and the volume of interest (VOI) of medial-, inter-, and lateral-condyle trabeculae were three-dimensional (3D) printed for uniaxial compression mechanical test and simulated by the finite element (FE) method. Results The results demonstrated that the O group indicated poorer trabecular architecture than the N group in three parts of the femoral condyle, especially in the intercondyle. Within the group, the BV/TV, trabecular thickness (Tb.Th), and trabecular number (Tb.N) ratios between the medial and lateral condyles were greater than 1 in both N and O groups. The medial condyle trabeculae's mechanical properties were higher than those of the lateral condyle, and this superiority appears to be broadened under osteoporotic conditions. FE modelling well reproduced these mechanical differentiations. Conclusions According to Wolff's law, the higher BV/TV and mechanical properties of the medial femoral condyle may be due to inherent imbalanced loading on the knee component. Alterations in BV/TV and their corresponding mechanical properties may accompany KOA.https://doi.org/10.1186/s12938-022-01039-xKneeFemoral condyle trabeculae3D printingFinite element methodMechanical properties |
| spellingShingle | Liqin Zheng Yuexing Dai Yongze Zheng Xingpeng He Minhui Wu Desheng Zheng ChiHung Li Yueguang Fan Ziling Lin Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method BioMedical Engineering OnLine Knee Femoral condyle trabeculae 3D printing Finite element method Mechanical properties |
| title | Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method |
| title_full | Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method |
| title_fullStr | Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method |
| title_full_unstemmed | Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method |
| title_short | Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method |
| title_sort | medial tibial plateau sustaining higher physiological stress than the lateral plateau based on 3d printing and finite element method |
| topic | Knee Femoral condyle trabeculae 3D printing Finite element method Mechanical properties |
| url | https://doi.org/10.1186/s12938-022-01039-x |
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