Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis
Multiple sclerosis: Understanding the role of melatonin Regulating melatonin levels holds promise as a therapy for multiple sclerosis (MS), but treatment must be tailored to each individual. In MS, the immune system destroys the myelin sheath surrounding nerves, disturbing brain–body communication....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-00925-1 |
| _version_ | 1797865461680963584 |
|---|---|
| author | Majid Ghareghani Vincent Pons Nataly Laflamme Kazem Zibara Serge Rivest |
| author_facet | Majid Ghareghani Vincent Pons Nataly Laflamme Kazem Zibara Serge Rivest |
| author_sort | Majid Ghareghani |
| collection | DOAJ |
| description | Multiple sclerosis: Understanding the role of melatonin Regulating melatonin levels holds promise as a therapy for multiple sclerosis (MS), but treatment must be tailored to each individual. In MS, the immune system destroys the myelin sheath surrounding nerves, disturbing brain–body communication. Melatonin, a sleep-inducing hormone, is known to play a role in MS, but results so far are inconsistent. Serge Rivest at Laval University in Québec City, Canada, and coworkers investigated how melatonin affects particular brain cell types in a mouse model. They found that maintaining melatonin levels at an intermediate level, where they regulate rather than enhance immune activity, could minimize myelin destruction in MS. They conclude that melatonin should not be considered a universal remedy for MS, but that melatonin levels should be monitored for each individual patient to account for lifestyle differences. |
| first_indexed | 2024-04-09T23:08:59Z |
| format | Article |
| id | doaj.art-3443e1a264ff45518e64207d1977c5d6 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-04-09T23:08:59Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-3443e1a264ff45518e64207d1977c5d62023-03-22T10:31:17ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-01-0155121522710.1038/s12276-023-00925-1Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosisMajid Ghareghani0Vincent Pons1Nataly Laflamme2Kazem Zibara3Serge Rivest4Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval UniversityNeuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval UniversityNeuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval UniversityPRASE and Biology Department, Faculty of Sciences-I, Lebanese UniversityNeuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval UniversityMultiple sclerosis: Understanding the role of melatonin Regulating melatonin levels holds promise as a therapy for multiple sclerosis (MS), but treatment must be tailored to each individual. In MS, the immune system destroys the myelin sheath surrounding nerves, disturbing brain–body communication. Melatonin, a sleep-inducing hormone, is known to play a role in MS, but results so far are inconsistent. Serge Rivest at Laval University in Québec City, Canada, and coworkers investigated how melatonin affects particular brain cell types in a mouse model. They found that maintaining melatonin levels at an intermediate level, where they regulate rather than enhance immune activity, could minimize myelin destruction in MS. They conclude that melatonin should not be considered a universal remedy for MS, but that melatonin levels should be monitored for each individual patient to account for lifestyle differences.https://doi.org/10.1038/s12276-023-00925-1 |
| spellingShingle | Majid Ghareghani Vincent Pons Nataly Laflamme Kazem Zibara Serge Rivest Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis Experimental and Molecular Medicine |
| title | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis |
| title_full | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis |
| title_fullStr | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis |
| title_full_unstemmed | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis |
| title_short | Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis |
| title_sort | inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes phagocytosis and myelination in a murine model of multiple sclerosis |
| url | https://doi.org/10.1038/s12276-023-00925-1 |
| work_keys_str_mv | AT majidghareghani inhibitingnighttimemelatoninandboostingcortisolincreasepatrollingmonocytesphagocytosisandmyelinationinamurinemodelofmultiplesclerosis AT vincentpons inhibitingnighttimemelatoninandboostingcortisolincreasepatrollingmonocytesphagocytosisandmyelinationinamurinemodelofmultiplesclerosis AT natalylaflamme inhibitingnighttimemelatoninandboostingcortisolincreasepatrollingmonocytesphagocytosisandmyelinationinamurinemodelofmultiplesclerosis AT kazemzibara inhibitingnighttimemelatoninandboostingcortisolincreasepatrollingmonocytesphagocytosisandmyelinationinamurinemodelofmultiplesclerosis AT sergerivest inhibitingnighttimemelatoninandboostingcortisolincreasepatrollingmonocytesphagocytosisandmyelinationinamurinemodelofmultiplesclerosis |