IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria
IL-25, IL-33 and TSLP, which are produced predominantly by epithelial cells, can induce production of Th2-type cytokines such as IL-4, IL-5 and/or IL-13 by various types of cells, suggesting their involvement in induction of Th2-type cytokine-associated immune responses. It is known that Th2-type cy...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580815001521 |
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| author | Akiko Shibui Ayako Takamori Mohammed E.M. Tolba Aya Nambu Eri Shimura Sachiko Yamaguchi Chizu Sanjoba Hajime Suto Katsuko Sudo Ko Okumura Sumio Sugano Hideaki Morita Hirohisa Saito Kenji Matsumoto Susumu Nakae |
| author_facet | Akiko Shibui Ayako Takamori Mohammed E.M. Tolba Aya Nambu Eri Shimura Sachiko Yamaguchi Chizu Sanjoba Hajime Suto Katsuko Sudo Ko Okumura Sumio Sugano Hideaki Morita Hirohisa Saito Kenji Matsumoto Susumu Nakae |
| author_sort | Akiko Shibui |
| collection | DOAJ |
| description | IL-25, IL-33 and TSLP, which are produced predominantly by epithelial cells, can induce production of Th2-type cytokines such as IL-4, IL-5 and/or IL-13 by various types of cells, suggesting their involvement in induction of Th2-type cytokine-associated immune responses. It is known that Th2-type cytokines contribute to host defense against malaria parasite infection in mice. However, the roles of IL-25, IL-33 and TSLP in malaria parasite infection remain unclear. Thus, to elucidate this, we infected wild-type, IL-25−/−, IL-33−/− and TSLP receptor (TSLPR)−/− mice with Plasmodium berghei (P. berghei) ANKA, a murine malaria strain. The expression levels of IL-25, IL-33 and TSLP mRNA were changed in the brain, liver, lung and spleen of wild-type mice after infection, suggesting that these cytokines are involved in host defense against P. berghei ANKA. However, the incidence of parasitemia and survival in the mutant mice were comparable to in the wild-type mice. These findings indicate that IL-25, IL-33 and TSLP are not critical for host defense against P. berghei ANKA. |
| first_indexed | 2024-12-10T03:31:01Z |
| format | Article |
| id | doaj.art-34451bc6ff1448b29d240097bd7fa8dc |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-10T03:31:01Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-34451bc6ff1448b29d240097bd7fa8dc2022-12-22T02:03:49ZengElsevierBiochemistry and Biophysics Reports2405-58082016-03-015C19119510.1016/j.bbrep.2015.12.007IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malariaAkiko Shibui0Ayako Takamori1Mohammed E.M. Tolba2Aya Nambu3Eri Shimura4Sachiko Yamaguchi5Chizu Sanjoba6Hajime Suto7Katsuko Sudo8Ko Okumura9Sumio Sugano10Hideaki Morita11Hirohisa Saito12Kenji Matsumoto13Susumu Nakae14Department of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, JapanLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, JapanLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Molecular Immunology, School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, JapanAtopy Research Center, Juntendo University, Tokyo 113-8412, JapanAnimal Research Center, Tokyo Medical University, Tokyo 160-8402, JapanAtopy Research Center, Juntendo University, Tokyo 113-8412, JapanDepartment of Medical Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, JapanDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, JapanDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, JapanDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo 157-8535, JapanLaboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanIL-25, IL-33 and TSLP, which are produced predominantly by epithelial cells, can induce production of Th2-type cytokines such as IL-4, IL-5 and/or IL-13 by various types of cells, suggesting their involvement in induction of Th2-type cytokine-associated immune responses. It is known that Th2-type cytokines contribute to host defense against malaria parasite infection in mice. However, the roles of IL-25, IL-33 and TSLP in malaria parasite infection remain unclear. Thus, to elucidate this, we infected wild-type, IL-25−/−, IL-33−/− and TSLP receptor (TSLPR)−/− mice with Plasmodium berghei (P. berghei) ANKA, a murine malaria strain. The expression levels of IL-25, IL-33 and TSLP mRNA were changed in the brain, liver, lung and spleen of wild-type mice after infection, suggesting that these cytokines are involved in host defense against P. berghei ANKA. However, the incidence of parasitemia and survival in the mutant mice were comparable to in the wild-type mice. These findings indicate that IL-25, IL-33 and TSLP are not critical for host defense against P. berghei ANKA.http://www.sciencedirect.com/science/article/pii/S2405580815001521Interleukin-25Interleukin-33Thymic stromal lymphoproteinMalariaMouse |
| spellingShingle | Akiko Shibui Ayako Takamori Mohammed E.M. Tolba Aya Nambu Eri Shimura Sachiko Yamaguchi Chizu Sanjoba Hajime Suto Katsuko Sudo Ko Okumura Sumio Sugano Hideaki Morita Hirohisa Saito Kenji Matsumoto Susumu Nakae IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria Biochemistry and Biophysics Reports Interleukin-25 Interleukin-33 Thymic stromal lymphoprotein Malaria Mouse |
| title | IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria |
| title_full | IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria |
| title_fullStr | IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria |
| title_full_unstemmed | IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria |
| title_short | IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria |
| title_sort | il 25 il 33 and tslp receptor are not critical for development of experimental murine malaria |
| topic | Interleukin-25 Interleukin-33 Thymic stromal lymphoprotein Malaria Mouse |
| url | http://www.sciencedirect.com/science/article/pii/S2405580815001521 |
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