Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus
Abstract Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride 25mg twice daily for 1 month. Objectiv...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-08-01
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| Series: | The Egyptian Journal of Otolaryngology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.4103/ejo.ejo_82_17 |
| _version_ | 1797203902726144000 |
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| author | Tamer A. Abo El Ezz Fathy N. Fattoh Tahany Rabie |
| author_facet | Tamer A. Abo El Ezz Fathy N. Fattoh Tahany Rabie |
| author_sort | Tamer A. Abo El Ezz |
| collection | DOAJ |
| description | Abstract Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride 25mg twice daily for 1 month. Objectives To assess the clinical benefit of adding dexamethasone by IT route to the tricyclic antidepressant imipramine hydrochloride in the management of idiopathic unilateral subjective tinnitus. Study design A prospective randomized clinical trial was conducted. Results Results from this study showed significant subjective improvement of patients with unilateral subjective tinnitus when comparing the two arms of the study, both to pretreatment assessment and between the two arms, giving significant advantage to the group treated with combination of intratympanic dexamethasone with imipramine hydrochloride 25mg twice daily for 2 weeks using tinnitus handicap inventory questionnaire, subjective tinnitus loudness as measured by a visual analog scale, and tinnitus awareness score. Conclusion Intratympanic dexamethasone injection in combination with TCA imipramine maleate could be subjectively beneficial when compared with imipramine hydrochloride alone. |
| first_indexed | 2024-04-24T08:26:43Z |
| format | Article |
| id | doaj.art-34461b63e5f24558b96beec3733a8194 |
| institution | Directory Open Access Journal |
| issn | 1012-5574 2090-8539 |
| language | English |
| last_indexed | 2024-04-24T08:26:43Z |
| publishDate | 2019-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Otolaryngology |
| spelling | doaj.art-34461b63e5f24558b96beec3733a81942024-04-16T22:06:31ZengSpringerOpenThe Egyptian Journal of Otolaryngology1012-55742090-85392019-08-0135330030610.4103/ejo.ejo_82_17Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitusTamer A. Abo El Ezz0Fathy N. Fattoh1Tahany Rabie2Department of ORL & Audiology, Ain Shams UniversityDepartment of ORL & Audiology, Ain Shams UniversityDepartment of ORL & Audiology, Ain Shams UniversityAbstract Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride 25mg twice daily for 1 month. Objectives To assess the clinical benefit of adding dexamethasone by IT route to the tricyclic antidepressant imipramine hydrochloride in the management of idiopathic unilateral subjective tinnitus. Study design A prospective randomized clinical trial was conducted. Results Results from this study showed significant subjective improvement of patients with unilateral subjective tinnitus when comparing the two arms of the study, both to pretreatment assessment and between the two arms, giving significant advantage to the group treated with combination of intratympanic dexamethasone with imipramine hydrochloride 25mg twice daily for 2 weeks using tinnitus handicap inventory questionnaire, subjective tinnitus loudness as measured by a visual analog scale, and tinnitus awareness score. Conclusion Intratympanic dexamethasone injection in combination with TCA imipramine maleate could be subjectively beneficial when compared with imipramine hydrochloride alone.http://link.springer.com/article/10.4103/ejo.ejo_82_17idiopathicintratympanic dexamethasoneTCAtinnitus |
| spellingShingle | Tamer A. Abo El Ezz Fathy N. Fattoh Tahany Rabie Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus The Egyptian Journal of Otolaryngology idiopathic intratympanic dexamethasone TCA tinnitus |
| title | Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| title_full | Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| title_fullStr | Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| title_full_unstemmed | Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| title_short | Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| title_sort | intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride tofranil a tca 25 mg twice daily in management of idiopathic unilateral subjective tinnitus |
| topic | idiopathic intratympanic dexamethasone TCA tinnitus |
| url | http://link.springer.com/article/10.4103/ejo.ejo_82_17 |
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