Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release
In this paper, a novel wound dressing membrane for controlled release of gentamicin (GE), while covering and protecting the wound was investigated. Chitosan (CHI) was associated with methoxy polyethylene glycol - polycaprolactone copolymer (mPEG-PCL) to prepare the blended wound dressing membranes....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2018-08-01
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| Series: | Materials Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000600207&tlng=en |
| _version_ | 1798021412895588352 |
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| author | Samira Faleiros Silva Brianezi Karine Cappuccio Castro Rodolfo Debone Piazza Maria do Socorro Fernandes Melo Rafael Matsumoto Pereira Rodrigo Fernando Costa Marques Maria Gabriela Nogueira Campos |
| author_facet | Samira Faleiros Silva Brianezi Karine Cappuccio Castro Rodolfo Debone Piazza Maria do Socorro Fernandes Melo Rafael Matsumoto Pereira Rodrigo Fernando Costa Marques Maria Gabriela Nogueira Campos |
| author_sort | Samira Faleiros Silva Brianezi |
| collection | DOAJ |
| description | In this paper, a novel wound dressing membrane for controlled release of gentamicin (GE), while covering and protecting the wound was investigated. Chitosan (CHI) was associated with methoxy polyethylene glycol - polycaprolactone copolymer (mPEG-PCL) to prepare the blended wound dressing membranes. The use of copolymer mPEG-PCL was necessary to improve the compatibility between CHI and PCL. The association of CHI and PCL was required to control the water retention and release rate of encapsulated GE. In vitro release studies were performed with the mPEG-PCL/CHI-GE membranes in order to evaluate the effect of copolymer concentration on the kinetics of GE release and water uptake. Reduced burst release rates and swelling ratios were observed for the 1/2 and 1/4 mPEG-PCL/CHI-GE membranes. In addition, all gentamicin-loaded membranes inhibited S. aureus and E. coli growth, and demonstrated color, moisture and thermal stability. Therefore, mPEG-PCL/CHI-GE membranes showed important features for potential wound dressing and drug delivery applications. |
| first_indexed | 2024-04-11T17:13:28Z |
| format | Article |
| id | doaj.art-34471cc4e2d04e82a0e146785e3f9d49 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-04-11T17:13:28Z |
| publishDate | 2018-08-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-34471cc4e2d04e82a0e146785e3f9d492022-12-22T04:12:49ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392018-08-0121610.1590/1980-5373-mr-2017-0951Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin ReleaseSamira Faleiros Silva BrianeziKarine Cappuccio CastroRodolfo Debone PiazzaMaria do Socorro Fernandes MeloRafael Matsumoto PereiraRodrigo Fernando Costa MarquesMaria Gabriela Nogueira CamposIn this paper, a novel wound dressing membrane for controlled release of gentamicin (GE), while covering and protecting the wound was investigated. Chitosan (CHI) was associated with methoxy polyethylene glycol - polycaprolactone copolymer (mPEG-PCL) to prepare the blended wound dressing membranes. The use of copolymer mPEG-PCL was necessary to improve the compatibility between CHI and PCL. The association of CHI and PCL was required to control the water retention and release rate of encapsulated GE. In vitro release studies were performed with the mPEG-PCL/CHI-GE membranes in order to evaluate the effect of copolymer concentration on the kinetics of GE release and water uptake. Reduced burst release rates and swelling ratios were observed for the 1/2 and 1/4 mPEG-PCL/CHI-GE membranes. In addition, all gentamicin-loaded membranes inhibited S. aureus and E. coli growth, and demonstrated color, moisture and thermal stability. Therefore, mPEG-PCL/CHI-GE membranes showed important features for potential wound dressing and drug delivery applications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000600207&tlng=enCopolymerblendmethoxy polyethylene glycolpolycaprolactoneantibioticdrug delivery |
| spellingShingle | Samira Faleiros Silva Brianezi Karine Cappuccio Castro Rodolfo Debone Piazza Maria do Socorro Fernandes Melo Rafael Matsumoto Pereira Rodrigo Fernando Costa Marques Maria Gabriela Nogueira Campos Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release Materials Research Copolymer blend methoxy polyethylene glycol polycaprolactone antibiotic drug delivery |
| title | Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release |
| title_full | Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release |
| title_fullStr | Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release |
| title_full_unstemmed | Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release |
| title_short | Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release |
| title_sort | preparation and characterization of chitosan mpeg pcl blended membranes for wound dressing and controlled gentamicin release |
| topic | Copolymer blend methoxy polyethylene glycol polycaprolactone antibiotic drug delivery |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000600207&tlng=en |
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