Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm
Russell’s viper (<i>Daboia russelii</i>), one of the ‘Big Four’ venomous snakes in India, is responsible for the majority of snakebite-induced deaths and permanent disabilities. Russell’s viper bites are known to induce bleeding/clotting abnormalities, as well as myotoxic, nephrotoxic, c...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/14/4/260 |
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| author | Subramanian Senthilkumaran Stephen W. Miller Harry F. Williams Rajendran Vaiyapuri Ravi Savania Namasivayam Elangovan Ponniah Thirumalaikolundusubramanian Ketan Patel Sakthivel Vaiyapuri |
| author_facet | Subramanian Senthilkumaran Stephen W. Miller Harry F. Williams Rajendran Vaiyapuri Ravi Savania Namasivayam Elangovan Ponniah Thirumalaikolundusubramanian Ketan Patel Sakthivel Vaiyapuri |
| author_sort | Subramanian Senthilkumaran |
| collection | DOAJ |
| description | Russell’s viper (<i>Daboia russelii</i>), one of the ‘Big Four’ venomous snakes in India, is responsible for the majority of snakebite-induced deaths and permanent disabilities. Russell’s viper bites are known to induce bleeding/clotting abnormalities, as well as myotoxic, nephrotoxic, cytotoxic and neurotoxic envenomation effects. In addition, they have been reported to induce rare envenomation effects such as priapism, sialolithiasis and splenic rupture. However, Russell’s viper bite-induced pseudoaneurysm (PA) has not been previously reported. PA or false aneurysm is a rare phenomenon that occurs in arteries following traumatic injuries including some animal bites, and it can become a life-threatening condition if not treated promptly. Here, we document two clinical cases of Russell’s viper bites where PA has developed, despite antivenom treatment. Notably, a non-surgical procedure, ultrasound-guided compression (USGC), either alone, or in combination with thrombin was effectively used in both the cases to treat the PA. Following this procedure and additional measures, the patients made complete recoveries without the recurrence of PA which were confirmed by subsequent examination and ultrasound scans. These data demonstrate the development of PA as a rare complication following Russell’s viper bites and the effective use of a simple, non-surgical procedure, USGC for the successful treatment of PA. These results will create awareness among healthcare professionals on the development of PA and the use of USGC in snakebite victims following bites from Russell’s vipers, as well as other viper bites. |
| first_indexed | 2024-03-09T04:09:28Z |
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| id | doaj.art-344abbbd3d114c6db6b224a08e1c7b45 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T04:09:28Z |
| publishDate | 2022-04-01 |
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| record_format | Article |
| series | Toxins |
| spelling | doaj.art-344abbbd3d114c6db6b224a08e1c7b452023-12-03T14:01:54ZengMDPI AGToxins2072-66512022-04-0114426010.3390/toxins14040260Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced PseudoaneurysmSubramanian Senthilkumaran0Stephen W. Miller1Harry F. Williams2Rajendran Vaiyapuri3Ravi Savania4Namasivayam Elangovan5Ponniah Thirumalaikolundusubramanian6Ketan Patel7Sakthivel Vaiyapuri8Emergency Department, Manian Medical Centre, Erode 638001, IndiaThe Poison Control Center, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USAResearch and Development Department, Toxiven Biotech Private Limited, Coimbatore 641042, IndiaResearch and Development Department, Toxiven Biotech Private Limited, Coimbatore 641042, IndiaSchool of Pharmacy, University of Reading, Reading RG6 6UB, UKDepartment of Biotechnology, School of Biosciences, Periyar University, Salem 636011, IndiaResearch Department, Trichy SRM Medical College Hospital & Research Centre, Trichy 621105, IndiaSchool of Biological Sciences, University of Reading, Reading RG6 6UB, UKSchool of Pharmacy, University of Reading, Reading RG6 6UB, UKRussell’s viper (<i>Daboia russelii</i>), one of the ‘Big Four’ venomous snakes in India, is responsible for the majority of snakebite-induced deaths and permanent disabilities. Russell’s viper bites are known to induce bleeding/clotting abnormalities, as well as myotoxic, nephrotoxic, cytotoxic and neurotoxic envenomation effects. In addition, they have been reported to induce rare envenomation effects such as priapism, sialolithiasis and splenic rupture. However, Russell’s viper bite-induced pseudoaneurysm (PA) has not been previously reported. PA or false aneurysm is a rare phenomenon that occurs in arteries following traumatic injuries including some animal bites, and it can become a life-threatening condition if not treated promptly. Here, we document two clinical cases of Russell’s viper bites where PA has developed, despite antivenom treatment. Notably, a non-surgical procedure, ultrasound-guided compression (USGC), either alone, or in combination with thrombin was effectively used in both the cases to treat the PA. Following this procedure and additional measures, the patients made complete recoveries without the recurrence of PA which were confirmed by subsequent examination and ultrasound scans. These data demonstrate the development of PA as a rare complication following Russell’s viper bites and the effective use of a simple, non-surgical procedure, USGC for the successful treatment of PA. These results will create awareness among healthcare professionals on the development of PA and the use of USGC in snakebite victims following bites from Russell’s vipers, as well as other viper bites.https://www.mdpi.com/2072-6651/14/4/260pseudoaneurysmsnakebite envenomationRussell’s viperultrasound-guided compressionulnar arterycolour Doppler imaging |
| spellingShingle | Subramanian Senthilkumaran Stephen W. Miller Harry F. Williams Rajendran Vaiyapuri Ravi Savania Namasivayam Elangovan Ponniah Thirumalaikolundusubramanian Ketan Patel Sakthivel Vaiyapuri Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm Toxins pseudoaneurysm snakebite envenomation Russell’s viper ultrasound-guided compression ulnar artery colour Doppler imaging |
| title | Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm |
| title_full | Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm |
| title_fullStr | Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm |
| title_full_unstemmed | Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm |
| title_short | Ultrasound-Guided Compression Method Effectively Counteracts Russell’s Viper Bite-Induced Pseudoaneurysm |
| title_sort | ultrasound guided compression method effectively counteracts russell s viper bite induced pseudoaneurysm |
| topic | pseudoaneurysm snakebite envenomation Russell’s viper ultrasound-guided compression ulnar artery colour Doppler imaging |
| url | https://www.mdpi.com/2072-6651/14/4/260 |
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