Contribution of bone marrow derived cells to pancreatic carcinogenesis
Pancreatic cancer is a complex, aggressive and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these strom...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00056/full |
| _version_ | 1819040673581498368 |
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| author | Christopher J Scarlett Christopher J Scarlett |
| author_facet | Christopher J Scarlett Christopher J Scarlett |
| author_sort | Christopher J Scarlett |
| collection | DOAJ |
| description | Pancreatic cancer is a complex, aggressive and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression and neovascularisation will be discussed. |
| first_indexed | 2024-12-21T09:12:50Z |
| format | Article |
| id | doaj.art-344c3dca167445d9999507327db8c37f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T09:12:50Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-344c3dca167445d9999507327db8c37f2022-12-21T19:09:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-03-01410.3389/fphys.2013.0005644950Contribution of bone marrow derived cells to pancreatic carcinogenesisChristopher J Scarlett0Christopher J Scarlett1University of NewcastleGarvan Institute of Medical ResearchPancreatic cancer is a complex, aggressive and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression and neovascularisation will be discussed.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00056/fullFibrosisImmunosuppressionPancreatic Stellate CellsPancreatic CancerStromaBone marrow derived stem cells |
| spellingShingle | Christopher J Scarlett Christopher J Scarlett Contribution of bone marrow derived cells to pancreatic carcinogenesis Frontiers in Physiology Fibrosis Immunosuppression Pancreatic Stellate Cells Pancreatic Cancer Stroma Bone marrow derived stem cells |
| title | Contribution of bone marrow derived cells to pancreatic carcinogenesis |
| title_full | Contribution of bone marrow derived cells to pancreatic carcinogenesis |
| title_fullStr | Contribution of bone marrow derived cells to pancreatic carcinogenesis |
| title_full_unstemmed | Contribution of bone marrow derived cells to pancreatic carcinogenesis |
| title_short | Contribution of bone marrow derived cells to pancreatic carcinogenesis |
| title_sort | contribution of bone marrow derived cells to pancreatic carcinogenesis |
| topic | Fibrosis Immunosuppression Pancreatic Stellate Cells Pancreatic Cancer Stroma Bone marrow derived stem cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00056/full |
| work_keys_str_mv | AT christopherjscarlett contributionofbonemarrowderivedcellstopancreaticcarcinogenesis AT christopherjscarlett contributionofbonemarrowderivedcellstopancreaticcarcinogenesis |