Targeting Ion Channel TRPM4

Targeting Ion Channel TRPM4

The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Further...

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Bibliographic Details
Main Authors:	Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian E. Gerber, Hugues Abriel, Martin Lochner, Christine Peinelt
Format:	Article
Language:	deu
Published:	Swiss Chemical Society 2022-12-01
Series:	CHIMIA
Subjects:	Cancer Cardiac disease TRPM4 Small-molecule inhibitors
Online Access:	https://chimia.ch/chimia/article/view/6185

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