The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study
Background: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation (TMS). To compare results from data acquired...
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| Format: | Article |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00703/full |
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| author | Maximilian J. Wessel Maximilian J. Wessel Laurijn R. Draaisma Laurijn R. Draaisma Takuya Morishita Takuya Morishita Friedhelm C. Hummel Friedhelm C. Hummel Friedhelm C. Hummel |
| author_facet | Maximilian J. Wessel Maximilian J. Wessel Laurijn R. Draaisma Laurijn R. Draaisma Takuya Morishita Takuya Morishita Friedhelm C. Hummel Friedhelm C. Hummel Friedhelm C. Hummel |
| author_sort | Maximilian J. Wessel |
| collection | DOAJ |
| description | Background: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation (TMS). To compare results from data acquired with different available setups and bring data together, it is inevitable to determine whether different TMS setups lead to comparable or differential results.Objective: We assessed and compared short intracortical inhibition (SICI) and intracortical facilitation (ICF) testing four different experimental conditions.Methods: SICI and ICF were studied with different stimulators (Magstim BiStim2 or MagVenture MagPro X100), waveforms (monophasic or biphasic), current directions (anterior-posterior or posterior-anterior) at interstimulus intervals (ISIs) of 1, 3, 10, 15 ms.Results: We were not able to detect differences for SICI and ICF, when comparing the tested conditions, except for 3 ms SICI in which the anterior-posterior current direction led to stronger modulation. Correlation analysis suggested comparability for 3 ms SICI for the Magstim monophasic posterior-anterior condition with both tested MagVenture conditions.Conclusions: 3 ms SICI data sets obtained with two different, commonly used stimulators (Magstim BiStim2 or MagVenture MagPro X100) with conventionally used stimulation parameters are largely comparable. This may allow the combination of data sets in an open science view. |
| first_indexed | 2024-12-17T06:38:00Z |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-17T06:38:00Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-344f3a9de798462ca280ca181a593cc62022-12-21T21:59:56ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-07-011310.3389/fnins.2019.00703460932The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison StudyMaximilian J. Wessel0Maximilian J. Wessel1Laurijn R. Draaisma2Laurijn R. Draaisma3Takuya Morishita4Takuya Morishita5Friedhelm C. Hummel6Friedhelm C. Hummel7Friedhelm C. Hummel8Defitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, SwitzerlandDefitech Chair of Clinical Neuroengineering, Clinique Romande de Réadaptation, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL Valais), Sion, SwitzerlandDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, SwitzerlandDefitech Chair of Clinical Neuroengineering, Clinique Romande de Réadaptation, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL Valais), Sion, SwitzerlandDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, SwitzerlandDefitech Chair of Clinical Neuroengineering, Clinique Romande de Réadaptation, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL Valais), Sion, SwitzerlandDefitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, SwitzerlandDefitech Chair of Clinical Neuroengineering, Clinique Romande de Réadaptation, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL Valais), Sion, SwitzerlandDepartment of Clinical Neuroscience, University of Geneva Medical School, Geneva, SwitzerlandBackground: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation (TMS). To compare results from data acquired with different available setups and bring data together, it is inevitable to determine whether different TMS setups lead to comparable or differential results.Objective: We assessed and compared short intracortical inhibition (SICI) and intracortical facilitation (ICF) testing four different experimental conditions.Methods: SICI and ICF were studied with different stimulators (Magstim BiStim2 or MagVenture MagPro X100), waveforms (monophasic or biphasic), current directions (anterior-posterior or posterior-anterior) at interstimulus intervals (ISIs) of 1, 3, 10, 15 ms.Results: We were not able to detect differences for SICI and ICF, when comparing the tested conditions, except for 3 ms SICI in which the anterior-posterior current direction led to stronger modulation. Correlation analysis suggested comparability for 3 ms SICI for the Magstim monophasic posterior-anterior condition with both tested MagVenture conditions.Conclusions: 3 ms SICI data sets obtained with two different, commonly used stimulators (Magstim BiStim2 or MagVenture MagPro X100) with conventionally used stimulation parameters are largely comparable. This may allow the combination of data sets in an open science view.https://www.frontiersin.org/article/10.3389/fnins.2019.00703/fulltranscranial magnetic stimulationshort intracortical inhibitionintracortical facilitationMagstimMagVenturecomparison |
| spellingShingle | Maximilian J. Wessel Maximilian J. Wessel Laurijn R. Draaisma Laurijn R. Draaisma Takuya Morishita Takuya Morishita Friedhelm C. Hummel Friedhelm C. Hummel Friedhelm C. Hummel The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study Frontiers in Neuroscience transcranial magnetic stimulation short intracortical inhibition intracortical facilitation Magstim MagVenture comparison |
| title | The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study |
| title_full | The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study |
| title_fullStr | The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study |
| title_full_unstemmed | The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study |
| title_short | The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study |
| title_sort | effects of stimulator waveform and current direction on intracortical inhibition and facilitation a tms comparison study |
| topic | transcranial magnetic stimulation short intracortical inhibition intracortical facilitation Magstim MagVenture comparison |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00703/full |
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