Reactive oxygen species-responsive polymer drug delivery systems
Applying reactive polymer materials sensitive to biological stimuli has recently attracted extensive research interest. The special physiological effects of reactive oxygen species (ROS) on tumors or inflammation and the application of ROS-responsive polymers as drug-delivery systems in organisms ha...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1115603/full |
| _version_ | 1797935305769091072 |
|---|---|
| author | Jiaxue Liu Boyan Jia Zhibo Li Wenliang Li |
| author_facet | Jiaxue Liu Boyan Jia Zhibo Li Wenliang Li |
| author_sort | Jiaxue Liu |
| collection | DOAJ |
| description | Applying reactive polymer materials sensitive to biological stimuli has recently attracted extensive research interest. The special physiological effects of reactive oxygen species (ROS) on tumors or inflammation and the application of ROS-responsive polymers as drug-delivery systems in organisms have attracted much attention. ROS is a vital disease signal molecule, and the unique accumulation of ROS-responsive polymers in pathological sites may enable ROS-responsive polymers to deliver payload (such as drugs, ROS-responsive prodrugs, and gene therapy fragments) in a targeted fashion. In this paper, the research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed. The research progress of ROS-responsive polymers was reviewed from the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels. It is expected that our work will help understand the future development trends in this field. |
| first_indexed | 2024-04-10T18:13:28Z |
| format | Article |
| id | doaj.art-3450fe5c401d4048b83dfdefa0a81b16 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T18:13:28Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-3450fe5c401d4048b83dfdefa0a81b162023-02-02T10:13:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-02-011110.3389/fbioe.2023.11156031115603Reactive oxygen species-responsive polymer drug delivery systemsJiaxue Liu0Boyan Jia1Zhibo Li2Wenliang Li3Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin, ChinaJilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin, ChinaDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, ChinaJilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin, ChinaApplying reactive polymer materials sensitive to biological stimuli has recently attracted extensive research interest. The special physiological effects of reactive oxygen species (ROS) on tumors or inflammation and the application of ROS-responsive polymers as drug-delivery systems in organisms have attracted much attention. ROS is a vital disease signal molecule, and the unique accumulation of ROS-responsive polymers in pathological sites may enable ROS-responsive polymers to deliver payload (such as drugs, ROS-responsive prodrugs, and gene therapy fragments) in a targeted fashion. In this paper, the research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed. The research progress of ROS-responsive polymers was reviewed from the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels. It is expected that our work will help understand the future development trends in this field.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1115603/fullreactive oxygen species (ROS)ROS-responsivenanoparticlehydrogelstimuli-responsive |
| spellingShingle | Jiaxue Liu Boyan Jia Zhibo Li Wenliang Li Reactive oxygen species-responsive polymer drug delivery systems Frontiers in Bioengineering and Biotechnology reactive oxygen species (ROS) ROS-responsive nanoparticle hydrogel stimuli-responsive |
| title | Reactive oxygen species-responsive polymer drug delivery systems |
| title_full | Reactive oxygen species-responsive polymer drug delivery systems |
| title_fullStr | Reactive oxygen species-responsive polymer drug delivery systems |
| title_full_unstemmed | Reactive oxygen species-responsive polymer drug delivery systems |
| title_short | Reactive oxygen species-responsive polymer drug delivery systems |
| title_sort | reactive oxygen species responsive polymer drug delivery systems |
| topic | reactive oxygen species (ROS) ROS-responsive nanoparticle hydrogel stimuli-responsive |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1115603/full |
| work_keys_str_mv | AT jiaxueliu reactiveoxygenspeciesresponsivepolymerdrugdeliverysystems AT boyanjia reactiveoxygenspeciesresponsivepolymerdrugdeliverysystems AT zhiboli reactiveoxygenspeciesresponsivepolymerdrugdeliverysystems AT wenliangli reactiveoxygenspeciesresponsivepolymerdrugdeliverysystems |