328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin
OBJECTIVES/GOALS: Tropsensor, a noninvasive portable device using infrared spectroscopy, delivers a troponin res ult within five minutes, significantly quicker than standard of care (SOC) assays. This pilot study assesses the correlation of the Tropsensor and high sensitivity cardiac troponin (hs-cT...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-04-01
|
| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205986612300376X/type/journal_article |
| _version_ | 1797840393769844736 |
|---|---|
| author | Sam McDonald Jessie Katz Jitto Titus Siddharth Biswal Atandra Burman Kartik Agusala Deborah Diercks Rebecca Vigen |
| author_facet | Sam McDonald Jessie Katz Jitto Titus Siddharth Biswal Atandra Burman Kartik Agusala Deborah Diercks Rebecca Vigen |
| author_sort | Sam McDonald |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Tropsensor, a noninvasive portable device using infrared spectroscopy, delivers a troponin res ult within five minutes, significantly quicker than standard of care (SOC) assays. This pilot study assesses the correlation of the Tropsensor and high sensitivity cardiac troponin (hs-cTnI) assay results. METHODS/STUDY POPULATION: Patients undergoing cTnI testing with the Abbott Architect STAT (Abbott Laboratories) hs-cTnI assay were recruited at a quaternary-care emergency department (ED). The Tropsensor was applied to the underside of the patients’ wrist within 5 minutes of the SOC blood draw for 5 minutes. The results of the hs-cTnI assays were compared with the raw output of the Tropsensor device to assess the relationship using both Spearman’s and nonlinear logarithmic measures of correlation. Patient demographic data was extracted from the EHR to supplement the data collected for this study. RESULTS/ANTICIPATED RESULTS: 58 patients were recruited with a mean age of 60 years (60% male, 40% female). Due to connection error, 8 patients’data did not get captured by the device. Additionally, due to noise related to suboptimal device contact with the wrist, 24 patients’data (41%) were rejected. Of the 26 patients with usable data, 9 patients had a troponin above the 99th percentile threshold. A nonlinear correlation of 0.64 and Spearman’s rho of 0.59 were observed between the SOC hs-cTnI assay and Tropsensor optical data. DISCUSSION/SIGNIFICANCE: The Tropsensor exhibits 64.4% correlation to the SOC hs-cTnI assay. While further evaluation is needed, this exploratory study provides insight into the potential of a transdermal optical device to be used as a screening tool for AMI in an ED triage situation. |
| first_indexed | 2024-04-09T16:14:23Z |
| format | Article |
| id | doaj.art-34513843f1ae448296ec75cbd52d3d69 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-09T16:14:23Z |
| publishDate | 2023-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-34513843f1ae448296ec75cbd52d3d692023-04-24T05:55:57ZengCambridge University PressJournal of Clinical and Translational Science2059-86612023-04-017989810.1017/cts.2023.376328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac TroponinSam McDonald0Jessie Katz1Jitto Titus2Siddharth Biswal3Atandra Burman4Kartik Agusala5Deborah Diercks6Rebecca Vigen7UT Southwestern(RCE)(RCE)(RCE)(RCE)(UTSW)(UTSW)(UTSW)OBJECTIVES/GOALS: Tropsensor, a noninvasive portable device using infrared spectroscopy, delivers a troponin res ult within five minutes, significantly quicker than standard of care (SOC) assays. This pilot study assesses the correlation of the Tropsensor and high sensitivity cardiac troponin (hs-cTnI) assay results. METHODS/STUDY POPULATION: Patients undergoing cTnI testing with the Abbott Architect STAT (Abbott Laboratories) hs-cTnI assay were recruited at a quaternary-care emergency department (ED). The Tropsensor was applied to the underside of the patients’ wrist within 5 minutes of the SOC blood draw for 5 minutes. The results of the hs-cTnI assays were compared with the raw output of the Tropsensor device to assess the relationship using both Spearman’s and nonlinear logarithmic measures of correlation. Patient demographic data was extracted from the EHR to supplement the data collected for this study. RESULTS/ANTICIPATED RESULTS: 58 patients were recruited with a mean age of 60 years (60% male, 40% female). Due to connection error, 8 patients’data did not get captured by the device. Additionally, due to noise related to suboptimal device contact with the wrist, 24 patients’data (41%) were rejected. Of the 26 patients with usable data, 9 patients had a troponin above the 99th percentile threshold. A nonlinear correlation of 0.64 and Spearman’s rho of 0.59 were observed between the SOC hs-cTnI assay and Tropsensor optical data. DISCUSSION/SIGNIFICANCE: The Tropsensor exhibits 64.4% correlation to the SOC hs-cTnI assay. While further evaluation is needed, this exploratory study provides insight into the potential of a transdermal optical device to be used as a screening tool for AMI in an ED triage situation.https://www.cambridge.org/core/product/identifier/S205986612300376X/type/journal_article |
| spellingShingle | Sam McDonald Jessie Katz Jitto Titus Siddharth Biswal Atandra Burman Kartik Agusala Deborah Diercks Rebecca Vigen 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin Journal of Clinical and Translational Science |
| title | 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin |
| title_full | 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin |
| title_fullStr | 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin |
| title_full_unstemmed | 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin |
| title_short | 328 Rapid Screening Tool for Identifying Acute Myocardial Injury: An Exploratory Study Evaluating the Ability of a Novel, Noninvasive Device to Detect Cardiac Troponin |
| title_sort | 328 rapid screening tool for identifying acute myocardial injury an exploratory study evaluating the ability of a novel noninvasive device to detect cardiac troponin |
| url | https://www.cambridge.org/core/product/identifier/S205986612300376X/type/journal_article |
| work_keys_str_mv | AT sammcdonald 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT jessiekatz 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT jittotitus 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT siddharthbiswal 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT atandraburman 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT kartikagusala 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT deborahdiercks 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin AT rebeccavigen 328rapidscreeningtoolforidentifyingacutemyocardialinjuryanexploratorystudyevaluatingtheabilityofanovelnoninvasivedevicetodetectcardiactroponin |