Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study
Abstract Background Fatigue is a core symptom of major depressive disorder (MDD) and is frequently refractory to antidepressant treatment, leading to unfavorable clinical/psychosocial outcomes. Dysfunctional self-reported interoception (i.e., maladaptive focus on the body’s physiological condition)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-05168-y |
| _version_ | 1797557363327107072 |
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| author | Michael Eggart Juan Valdés-Stauber Bruno Müller-Oerlinghausen Martin Heinze |
| author_facet | Michael Eggart Juan Valdés-Stauber Bruno Müller-Oerlinghausen Martin Heinze |
| author_sort | Michael Eggart |
| collection | DOAJ |
| description | Abstract Background Fatigue is a core symptom of major depressive disorder (MDD) and is frequently refractory to antidepressant treatment, leading to unfavorable clinical/psychosocial outcomes. Dysfunctional self-reported interoception (i.e., maladaptive focus on the body’s physiological condition) is prevalent in MDD and could contribute to residual symptom burden of fatigue. Therefore, we explored (a.) cross-sectional correlations between both dimensions and investigated (b.) prospective associations between interoceptive impairments at admission and symptom severity of fatigue at the end of hospitalization. Methods This observational, exploratory study included 87 patients suffering from MDD who completed self-rating scales, the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2), and the Multidimensional Fatigue Inventory (MFI-20), at the beginning and end of hospitalization. Bivariate correlations (r) and hierarchical regression analyses were performed. Results The cross-sectional analysis showed moderate to large negative correlations between the MAIA-2 and MFI-20 dimensions except for the Not-Distracting scale. Symptoms of general, physical, and mental fatigue at the end of hospitalization were predicted by reduced body Trusting (β = -.31, p = .01; β = -.28, p = .02; β = -.31, p = .00, respectively). Increased Body Listening (β = .37, p = .00), Not-Worrying (β = .26, p = .02), and diminished Attention Regulation (β = -.32, p = .01) predicted higher mental fatigue. Conclusions Diminished body confidence at baseline identified patients at risk for post-treatment fatigue and could therefore serve as a target for improving antidepressant therapy. Body-centered, integrative approaches could address treatment-resistant fatigue in MDD. However, clinicians may also consider the potential adverse effect of increased Body Listening and Not-Worrying on mental fatigue in psychotherapeutic and counselling approaches. Due to the exploratory nature of this study, the results are preliminary and need to be replicated in pre-registered trials with larger sample sizes. |
| first_indexed | 2024-03-10T17:16:03Z |
| format | Article |
| id | doaj.art-345244986f324100838f3275bab39a56 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-10T17:16:03Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-345244986f324100838f3275bab39a562023-11-20T10:29:13ZengBMCBMC Psychiatry1471-244X2023-09-0123111210.1186/s12888-023-05168-yDysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational studyMichael Eggart0Juan Valdés-Stauber1Bruno Müller-Oerlinghausen2Martin Heinze3Faculty of Health Sciences, Brandenburg Medical School Theodor FontaneDepartment of Psychiatry and Psychotherapy I, Ulm University and Center for Psychiatry SüdwürttembergFaculty of Medicine and Psychology, Brandenburg Medical School Theodor FontaneFaculty of Health Sciences, Brandenburg Medical School Theodor FontaneAbstract Background Fatigue is a core symptom of major depressive disorder (MDD) and is frequently refractory to antidepressant treatment, leading to unfavorable clinical/psychosocial outcomes. Dysfunctional self-reported interoception (i.e., maladaptive focus on the body’s physiological condition) is prevalent in MDD and could contribute to residual symptom burden of fatigue. Therefore, we explored (a.) cross-sectional correlations between both dimensions and investigated (b.) prospective associations between interoceptive impairments at admission and symptom severity of fatigue at the end of hospitalization. Methods This observational, exploratory study included 87 patients suffering from MDD who completed self-rating scales, the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2), and the Multidimensional Fatigue Inventory (MFI-20), at the beginning and end of hospitalization. Bivariate correlations (r) and hierarchical regression analyses were performed. Results The cross-sectional analysis showed moderate to large negative correlations between the MAIA-2 and MFI-20 dimensions except for the Not-Distracting scale. Symptoms of general, physical, and mental fatigue at the end of hospitalization were predicted by reduced body Trusting (β = -.31, p = .01; β = -.28, p = .02; β = -.31, p = .00, respectively). Increased Body Listening (β = .37, p = .00), Not-Worrying (β = .26, p = .02), and diminished Attention Regulation (β = -.32, p = .01) predicted higher mental fatigue. Conclusions Diminished body confidence at baseline identified patients at risk for post-treatment fatigue and could therefore serve as a target for improving antidepressant therapy. Body-centered, integrative approaches could address treatment-resistant fatigue in MDD. However, clinicians may also consider the potential adverse effect of increased Body Listening and Not-Worrying on mental fatigue in psychotherapeutic and counselling approaches. Due to the exploratory nature of this study, the results are preliminary and need to be replicated in pre-registered trials with larger sample sizes.https://doi.org/10.1186/s12888-023-05168-yMajor depressive disorderInteroceptionBody awarenessFatigueResidual symptomsOutcome predictors |
| spellingShingle | Michael Eggart Juan Valdés-Stauber Bruno Müller-Oerlinghausen Martin Heinze Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study BMC Psychiatry Major depressive disorder Interoception Body awareness Fatigue Residual symptoms Outcome predictors |
| title | Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study |
| title_full | Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study |
| title_fullStr | Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study |
| title_full_unstemmed | Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study |
| title_short | Dysfunctional self-reported interoception predicts residual symptom burden of fatigue in major depressive disorder: an observational study |
| title_sort | dysfunctional self reported interoception predicts residual symptom burden of fatigue in major depressive disorder an observational study |
| topic | Major depressive disorder Interoception Body awareness Fatigue Residual symptoms Outcome predictors |
| url | https://doi.org/10.1186/s12888-023-05168-y |
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