Suppressors of Cytokine Signaling and Hepatocellular Carcinoma
Cytokines are secreted soluble glycoproteins that regulate cellular growth, proliferation, and differentiation. Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling and form a classical negative feedback loop in the signaling pathways. There are eight members of t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2549 |
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| author | Ryota Masuzaki Tatsuo Kanda Reina Sasaki Naoki Matsumoto Kazushige Nirei Masahiro Ogawa Seth J. Karp Mitsuhiko Moriyama Hirofumi Kogure |
| author_facet | Ryota Masuzaki Tatsuo Kanda Reina Sasaki Naoki Matsumoto Kazushige Nirei Masahiro Ogawa Seth J. Karp Mitsuhiko Moriyama Hirofumi Kogure |
| author_sort | Ryota Masuzaki |
| collection | DOAJ |
| description | Cytokines are secreted soluble glycoproteins that regulate cellular growth, proliferation, and differentiation. Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling and form a classical negative feedback loop in the signaling pathways. There are eight members of the SOCS family. The SOCS proteins are all comprised of a loosely conserved N-terminal domain, a central Src homology 2 (SH2) domain, and a highly conserved SOCS box at the C-terminus. The role of SOCS proteins has been implicated in the regulation of cytokines and growth factors in liver diseases. The SOCS1 and SOCS3 proteins are involved in immune response and inhibit protective interferon signaling in viral hepatitis. A decreased expression of SOCS3 is associated with advanced stage and poor prognosis of patients with hepatocellular carcinoma (HCC). DNA methylations of SOCS1 and SOCS3 are found in HCC. Precise regulation of liver regeneration is influenced by stimulatory and inhibitory factors after partial hepatectomy (PH), in particular, SOCS2 and SOCS3 are induced at an early time point after PH. Evidence supporting the important role of SOCS signaling during liver regeneration also supports a role of SOCS signaling in HCC. Immuno-oncology drugs are now the first-line therapy for advanced HCC. The SOCS can be potential targets for HCC in terms of cell proliferation, cell differentiation, and immune response. In this literature review, we summarize recent findings of the SOCS family proteins related to HCC and liver diseases. |
| first_indexed | 2024-03-10T03:11:24Z |
| format | Article |
| id | doaj.art-3452af697a504953959390552133af4a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:11:24Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3452af697a504953959390552133af4a2023-11-23T10:24:45ZengMDPI AGCancers2072-66942022-05-011410254910.3390/cancers14102549Suppressors of Cytokine Signaling and Hepatocellular CarcinomaRyota Masuzaki0Tatsuo Kanda1Reina Sasaki2Naoki Matsumoto3Kazushige Nirei4Masahiro Ogawa5Seth J. Karp6Mitsuhiko Moriyama7Hirofumi Kogure8Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, JapanCytokines are secreted soluble glycoproteins that regulate cellular growth, proliferation, and differentiation. Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling and form a classical negative feedback loop in the signaling pathways. There are eight members of the SOCS family. The SOCS proteins are all comprised of a loosely conserved N-terminal domain, a central Src homology 2 (SH2) domain, and a highly conserved SOCS box at the C-terminus. The role of SOCS proteins has been implicated in the regulation of cytokines and growth factors in liver diseases. The SOCS1 and SOCS3 proteins are involved in immune response and inhibit protective interferon signaling in viral hepatitis. A decreased expression of SOCS3 is associated with advanced stage and poor prognosis of patients with hepatocellular carcinoma (HCC). DNA methylations of SOCS1 and SOCS3 are found in HCC. Precise regulation of liver regeneration is influenced by stimulatory and inhibitory factors after partial hepatectomy (PH), in particular, SOCS2 and SOCS3 are induced at an early time point after PH. Evidence supporting the important role of SOCS signaling during liver regeneration also supports a role of SOCS signaling in HCC. Immuno-oncology drugs are now the first-line therapy for advanced HCC. The SOCS can be potential targets for HCC in terms of cell proliferation, cell differentiation, and immune response. In this literature review, we summarize recent findings of the SOCS family proteins related to HCC and liver diseases.https://www.mdpi.com/2072-6694/14/10/2549hepatocellular carcinomasuppressor of cytokine signalingliver regeneration |
| spellingShingle | Ryota Masuzaki Tatsuo Kanda Reina Sasaki Naoki Matsumoto Kazushige Nirei Masahiro Ogawa Seth J. Karp Mitsuhiko Moriyama Hirofumi Kogure Suppressors of Cytokine Signaling and Hepatocellular Carcinoma Cancers hepatocellular carcinoma suppressor of cytokine signaling liver regeneration |
| title | Suppressors of Cytokine Signaling and Hepatocellular Carcinoma |
| title_full | Suppressors of Cytokine Signaling and Hepatocellular Carcinoma |
| title_fullStr | Suppressors of Cytokine Signaling and Hepatocellular Carcinoma |
| title_full_unstemmed | Suppressors of Cytokine Signaling and Hepatocellular Carcinoma |
| title_short | Suppressors of Cytokine Signaling and Hepatocellular Carcinoma |
| title_sort | suppressors of cytokine signaling and hepatocellular carcinoma |
| topic | hepatocellular carcinoma suppressor of cytokine signaling liver regeneration |
| url | https://www.mdpi.com/2072-6694/14/10/2549 |
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