Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel
A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatibl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/11/4390 |
| _version_ | 1827739343342534656 |
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| author | Dona Imanga Upamadi Edirisinghe Areetha D’Souza Maryam Ramezani Robert J. Carroll Quenten Chicón Cheyene L. Muenzel Jonathan Soule Mary Beth Browning Monroe Alison E. Patteson Olga V. Makhlynets |
| author_facet | Dona Imanga Upamadi Edirisinghe Areetha D’Souza Maryam Ramezani Robert J. Carroll Quenten Chicón Cheyene L. Muenzel Jonathan Soule Mary Beth Browning Monroe Alison E. Patteson Olga V. Makhlynets |
| author_sort | Dona Imanga Upamadi Edirisinghe |
| collection | DOAJ |
| description | A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions of patients each year. |
| first_indexed | 2024-03-11T03:01:25Z |
| format | Article |
| id | doaj.art-34572ecdcd804feb88d3c4e73b0fcff0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:01:25Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-34572ecdcd804feb88d3c4e73b0fcff02023-11-18T08:15:58ZengMDPI AGMolecules1420-30492023-05-012811439010.3390/molecules28114390Antibacterial and Cytocompatible pH-Responsive Peptide HydrogelDona Imanga Upamadi Edirisinghe0Areetha D’Souza1Maryam Ramezani2Robert J. Carroll3Quenten Chicón4Cheyene L. Muenzel5Jonathan Soule6Mary Beth Browning Monroe7Alison E. Patteson8Olga V. Makhlynets9Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USADepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USABiomedical and Chemical Engineering, Syracuse University, Bowne Hall, Syracuse, NY 13210, USADepartment of Physics, Syracuse University, Syracuse, NY 13210, USADepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USADepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USADepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USABiomedical and Chemical Engineering, Syracuse University, Bowne Hall, Syracuse, NY 13210, USADepartment of Physics, Syracuse University, Syracuse, NY 13210, USADepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USAA short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions of patients each year.https://www.mdpi.com/1420-3049/28/11/4390hydrogelpH sensitiveantimicrobialcytocompatibleself-healingrheology |
| spellingShingle | Dona Imanga Upamadi Edirisinghe Areetha D’Souza Maryam Ramezani Robert J. Carroll Quenten Chicón Cheyene L. Muenzel Jonathan Soule Mary Beth Browning Monroe Alison E. Patteson Olga V. Makhlynets Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel Molecules hydrogel pH sensitive antimicrobial cytocompatible self-healing rheology |
| title | Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel |
| title_full | Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel |
| title_fullStr | Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel |
| title_full_unstemmed | Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel |
| title_short | Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel |
| title_sort | antibacterial and cytocompatible ph responsive peptide hydrogel |
| topic | hydrogel pH sensitive antimicrobial cytocompatible self-healing rheology |
| url | https://www.mdpi.com/1420-3049/28/11/4390 |
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