Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016
Abstract Background It was recently shown that new-onset diabetes patients without previous cardiovascular disease have experienced a markedly reduced risk of adverse cardiovascular events from 1996 to 2011. However, it remains unknown if similar improvements are present following the diagnosis of c...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02312-y |
| _version_ | 1830194054206324736 |
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| author | Esben Skov Jensen Kevin Kris Warnakula Olesen Christine Gyldenkerne Pernille Gro Thrane Lisette Okkels Jensen Bent Raungaard Per Løgstrup Poulsen Reimar Wernich Thomsen Michael Maeng |
| author_facet | Esben Skov Jensen Kevin Kris Warnakula Olesen Christine Gyldenkerne Pernille Gro Thrane Lisette Okkels Jensen Bent Raungaard Per Løgstrup Poulsen Reimar Wernich Thomsen Michael Maeng |
| author_sort | Esben Skov Jensen |
| collection | DOAJ |
| description | Abstract Background It was recently shown that new-onset diabetes patients without previous cardiovascular disease have experienced a markedly reduced risk of adverse cardiovascular events from 1996 to 2011. However, it remains unknown if similar improvements are present following the diagnosis of chronic coronary syndrome. The purpose of this study was to examine the change in cardiovascular risk among diabetes patients with chronic coronary syndrome from 2004 to 2016. Methods We included patients with documentation of coronary artery disease by coronary angiography between 2004 and 2016 in Western Denmark. Patients were stratified by year of index coronary angiography (2004–2006, 2007–2009, 2010–2012, and 2013–2016) and followed for two years. The main outcome was major adverse cardiovascular events (MACE) defined as myocardial infarction, ischemic stroke, or death. Analyses were performed separately in patients with and without diabetes. We estimated two-year risk of each outcome and adjusted incidence rate ratios (aIRR) using patients examined in 2004-2006 as reference. Results Among 5931 patients with diabetes, two-year MACE risks were 8.4% in 2004–2006, 8.5% in 2007–2009, and then decreased to 6.2% in 2010–2012 and 6.7% in 2013–2016 (2013–2016 vs 2004–2006: aIRR 0.70, 95% CI 0.53–0.93). In comparison, 23,540 patients without diabetes had event rates of 6.3%, 5.2%, 4.2%, and 3.9% for the study intervals (2013–2016 vs 2004–2006: aIRR 0.57, 95% CI 0.48–0.68). Conclusions Between 2004 and 2016, the two-year relative risk of MACE decreased by 30% in patients with diabetes and chronic coronary syndrome, but slightly larger absolute and relative reductions were observed in patients without diabetes. |
| first_indexed | 2024-12-18T00:24:23Z |
| format | Article |
| id | doaj.art-3457b80406c248079fbc753f99fc934f |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-18T00:24:23Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-3457b80406c248079fbc753f99fc934f2022-12-21T21:27:17ZengBMCBMC Cardiovascular Disorders1471-22612021-12-0121111310.1186/s12872-021-02312-yCardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016Esben Skov Jensen0Kevin Kris Warnakula Olesen1Christine Gyldenkerne2Pernille Gro Thrane3Lisette Okkels Jensen4Bent Raungaard5Per Løgstrup Poulsen6Reimar Wernich Thomsen7Michael Maeng8Department of Cardiology, Aarhus University HospitalDepartment of Cardiology, Aarhus University HospitalDepartment of Cardiology, Aarhus University HospitalDepartment of Cardiology, Aarhus University HospitalDepartment of Cardiology, Odense University HospitalDepartment of Cardiology, Aalborg University HospitalSteno Diabetes Center Aarhus, Aarhus University HospitalDepartment of Clinical Epidemiology, Aarhus University HospitalDepartment of Cardiology, Aarhus University HospitalAbstract Background It was recently shown that new-onset diabetes patients without previous cardiovascular disease have experienced a markedly reduced risk of adverse cardiovascular events from 1996 to 2011. However, it remains unknown if similar improvements are present following the diagnosis of chronic coronary syndrome. The purpose of this study was to examine the change in cardiovascular risk among diabetes patients with chronic coronary syndrome from 2004 to 2016. Methods We included patients with documentation of coronary artery disease by coronary angiography between 2004 and 2016 in Western Denmark. Patients were stratified by year of index coronary angiography (2004–2006, 2007–2009, 2010–2012, and 2013–2016) and followed for two years. The main outcome was major adverse cardiovascular events (MACE) defined as myocardial infarction, ischemic stroke, or death. Analyses were performed separately in patients with and without diabetes. We estimated two-year risk of each outcome and adjusted incidence rate ratios (aIRR) using patients examined in 2004-2006 as reference. Results Among 5931 patients with diabetes, two-year MACE risks were 8.4% in 2004–2006, 8.5% in 2007–2009, and then decreased to 6.2% in 2010–2012 and 6.7% in 2013–2016 (2013–2016 vs 2004–2006: aIRR 0.70, 95% CI 0.53–0.93). In comparison, 23,540 patients without diabetes had event rates of 6.3%, 5.2%, 4.2%, and 3.9% for the study intervals (2013–2016 vs 2004–2006: aIRR 0.57, 95% CI 0.48–0.68). Conclusions Between 2004 and 2016, the two-year relative risk of MACE decreased by 30% in patients with diabetes and chronic coronary syndrome, but slightly larger absolute and relative reductions were observed in patients without diabetes.https://doi.org/10.1186/s12872-021-02312-yDiabetesCoronary artery diseaseMajor adverse cardiovascular eventTrend |
| spellingShingle | Esben Skov Jensen Kevin Kris Warnakula Olesen Christine Gyldenkerne Pernille Gro Thrane Lisette Okkels Jensen Bent Raungaard Per Løgstrup Poulsen Reimar Wernich Thomsen Michael Maeng Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 BMC Cardiovascular Disorders Diabetes Coronary artery disease Major adverse cardiovascular event Trend |
| title | Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 |
| title_full | Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 |
| title_fullStr | Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 |
| title_full_unstemmed | Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 |
| title_short | Cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004–2016 |
| title_sort | cardiovascular risk in patients with and without diabetes presenting with chronic coronary syndrome in 2004 2016 |
| topic | Diabetes Coronary artery disease Major adverse cardiovascular event Trend |
| url | https://doi.org/10.1186/s12872-021-02312-y |
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