Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature
AbstractIntroduction Acute leukemia (AL) occurring in pregnancy is extremely rare, and its treatment is a clinical dilemma.Methods We retrospectively reviewed the medical records of our hospital from 2010 to 2019.Results Twenty-one patients were diagnosed with AL during pregnancy. Of whom, eighteen...
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| Format: | Article |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1908586 |
| _version_ | 1797385685086240768 |
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| author | Dengqin Zhu Doudou Tang Xiaoshan Chai Guangsen Zhang Yewei Wang |
| author_facet | Dengqin Zhu Doudou Tang Xiaoshan Chai Guangsen Zhang Yewei Wang |
| author_sort | Dengqin Zhu |
| collection | DOAJ |
| description | AbstractIntroduction Acute leukemia (AL) occurring in pregnancy is extremely rare, and its treatment is a clinical dilemma.Methods We retrospectively reviewed the medical records of our hospital from 2010 to 2019.Results Twenty-one patients were diagnosed with AL during pregnancy. Of whom, eighteen had acute myeloid leukemia, and 3 had acute lymphoblastic leukemia. Six, eight and seven patients were diagnosed during the first, second, and third trimester, respectively. Six of the 21 patients experienced therapeutic abortion and 1 had spontaneous abortion, whereas 9 gave birth to healthy babies (4 through vaginal deliveries and 5 with Caesarean sections). Four babies had been exposed to chemotherapeutic agents, but no congenital malformations were observed. Sixteen patients received chemotherapy, while 4 patients died before chemotherapy and one was discharged after refusing chemotherapy. The complete remission rate of the 10 patients who began chemotherapy immediately after diagnosis was 80%, compared with 66.7% in the 6 patients who started chemotherapy after abortion or delivery. Three remain alive.Conclusions In general, initiation of chemotherapy as early as possible may increase the CR rate. Combined with literature data, we proposed that, for patients diagnosed in early and late stages of pregnancy (>30 weeks), elective termination or induced delivery before chemotherapy may be a good choice for better maternal (and fetal) outcome.KEY MESSAGESAcute leukaemia diagnosed in pregnancy is extremely rare, and its treatment is a clinical dilemma.In general, initiation of chemotherapy as early as possible may increase the CR rate.For patients who are diagnosed in the first trimester or late stage of pregnancy (>30 weeks), elective termination or induced delivery before starting chemotherapy may be a good choice for better maternal (and fetal) outcome. |
| first_indexed | 2024-03-08T21:57:51Z |
| format | Article |
| id | doaj.art-345837964d864266a98df9fc4e9ef46e |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:57:51Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-345837964d864266a98df9fc4e9ef46e2023-12-19T16:46:28ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-0153156757510.1080/07853890.2021.1908586Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literatureDengqin Zhu0Doudou Tang1Xiaoshan Chai2Guangsen Zhang3Yewei Wang4Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Hunan Centre for Evidence-based Medicine, Central South University, Changsha, ChinaDepartment of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha, ChinaAbstractIntroduction Acute leukemia (AL) occurring in pregnancy is extremely rare, and its treatment is a clinical dilemma.Methods We retrospectively reviewed the medical records of our hospital from 2010 to 2019.Results Twenty-one patients were diagnosed with AL during pregnancy. Of whom, eighteen had acute myeloid leukemia, and 3 had acute lymphoblastic leukemia. Six, eight and seven patients were diagnosed during the first, second, and third trimester, respectively. Six of the 21 patients experienced therapeutic abortion and 1 had spontaneous abortion, whereas 9 gave birth to healthy babies (4 through vaginal deliveries and 5 with Caesarean sections). Four babies had been exposed to chemotherapeutic agents, but no congenital malformations were observed. Sixteen patients received chemotherapy, while 4 patients died before chemotherapy and one was discharged after refusing chemotherapy. The complete remission rate of the 10 patients who began chemotherapy immediately after diagnosis was 80%, compared with 66.7% in the 6 patients who started chemotherapy after abortion or delivery. Three remain alive.Conclusions In general, initiation of chemotherapy as early as possible may increase the CR rate. Combined with literature data, we proposed that, for patients diagnosed in early and late stages of pregnancy (>30 weeks), elective termination or induced delivery before chemotherapy may be a good choice for better maternal (and fetal) outcome.KEY MESSAGESAcute leukaemia diagnosed in pregnancy is extremely rare, and its treatment is a clinical dilemma.In general, initiation of chemotherapy as early as possible may increase the CR rate.For patients who are diagnosed in the first trimester or late stage of pregnancy (>30 weeks), elective termination or induced delivery before starting chemotherapy may be a good choice for better maternal (and fetal) outcome.https://www.tandfonline.com/doi/10.1080/07853890.2021.1908586Acute leukaemiapregnancychemotherapyacute myeloid leukaemiaacute lymphoblastic leukaemia |
| spellingShingle | Dengqin Zhu Doudou Tang Xiaoshan Chai Guangsen Zhang Yewei Wang Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature Annals of Medicine Acute leukaemia pregnancy chemotherapy acute myeloid leukaemia acute lymphoblastic leukaemia |
| title | Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature |
| title_full | Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature |
| title_fullStr | Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature |
| title_full_unstemmed | Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature |
| title_short | Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature |
| title_sort | acute leukemia in pregnancy a single institutional experience with 21 cases at 10 years and a review of the literature |
| topic | Acute leukaemia pregnancy chemotherapy acute myeloid leukaemia acute lymphoblastic leukaemia |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1908586 |
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