Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast
Abstract Objectives Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevale...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3296-7 |
| _version_ | 1818564823587225600 |
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| author | Stephane Koui Tossea Eric Gbessi Adji Baba Coulibaly Berenger Ako Ako David Ngolo Coulibaly Philippe Joly Serge-Brice Assi Andre Toure Ronan Jambou |
| author_facet | Stephane Koui Tossea Eric Gbessi Adji Baba Coulibaly Berenger Ako Ako David Ngolo Coulibaly Philippe Joly Serge-Brice Assi Andre Toure Ronan Jambou |
| author_sort | Stephane Koui Tossea |
| collection | DOAJ |
| description | Abstract Objectives Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevalence of abnormal hemoglobin among patients attending dispensaries for mild malaria is thus unknown. A retrospective study was conducted to update data on the prevalence of S and C hemoglobin among patients attending dispensaries with mild malaria. Enrolment of patients was conducted during in vivo malaria treatment efficacy survey following the 42 days WHO protocol. A group of non-infected pregnant women and a group of patients with fever different from malaria, were also recruited in the same dispensaries. Results 794 blood samples were included. S and C genotypes were found in all the regions of Ivory Coast with the highest prevalence in the Northern region (S and C genotypes, 27%). In non-infected patients, prevalence of mutations was higher than in malaria patients. Conclusion A high proportion of patients with mild malaria carried genetic hemoglobin disorder. This population of high risk must be better investigated to control treatment efficacy and to manage complications. |
| first_indexed | 2024-12-14T01:33:34Z |
| format | Article |
| id | doaj.art-3458f5e02cd94c9b99e576a7e8fd7a8a |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-14T01:33:34Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-3458f5e02cd94c9b99e576a7e8fd7a8a2022-12-21T23:21:57ZengBMCBMC Research Notes1756-05002018-04-011111710.1186/s13104-018-3296-7Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory CoastStephane Koui Tossea0Eric Gbessi Adji1Baba Coulibaly2Berenger Ako Ako3David Ngolo Coulibaly4Philippe Joly5Serge-Brice Assi6Andre Toure7Ronan Jambou8Departement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireUniv Lyon, University Claude Bernard Lyon 1, EA 7424Programme National de Lutte Contre le Paludisme, Ministère de la SantéDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireDepartement de Parasitologie Mycologie, Institut Pasteur de Côte d’IvoireAbstract Objectives Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevalence of abnormal hemoglobin among patients attending dispensaries for mild malaria is thus unknown. A retrospective study was conducted to update data on the prevalence of S and C hemoglobin among patients attending dispensaries with mild malaria. Enrolment of patients was conducted during in vivo malaria treatment efficacy survey following the 42 days WHO protocol. A group of non-infected pregnant women and a group of patients with fever different from malaria, were also recruited in the same dispensaries. Results 794 blood samples were included. S and C genotypes were found in all the regions of Ivory Coast with the highest prevalence in the Northern region (S and C genotypes, 27%). In non-infected patients, prevalence of mutations was higher than in malaria patients. Conclusion A high proportion of patients with mild malaria carried genetic hemoglobin disorder. This population of high risk must be better investigated to control treatment efficacy and to manage complications.http://link.springer.com/article/10.1186/s13104-018-3296-7Sickle cell anemiaMalariaIvory CoastFRET |
| spellingShingle | Stephane Koui Tossea Eric Gbessi Adji Baba Coulibaly Berenger Ako Ako David Ngolo Coulibaly Philippe Joly Serge-Brice Assi Andre Toure Ronan Jambou Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast BMC Research Notes Sickle cell anemia Malaria Ivory Coast FRET |
| title | Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast |
| title_full | Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast |
| title_fullStr | Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast |
| title_full_unstemmed | Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast |
| title_short | Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast |
| title_sort | cross sectional study on prevalence of sickle cell alleles s and c among patients with mild malaria in ivory coast |
| topic | Sickle cell anemia Malaria Ivory Coast FRET |
| url | http://link.springer.com/article/10.1186/s13104-018-3296-7 |
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