Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study.
<h4>Objective</h4>To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyz...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0222598 |
| _version_ | 1819093429391458304 |
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| author | Shoko Tamaki Akio Kanazawa Junko Sato Yoshifumi Tamura Takashi Asahara Takuya Takahashi Satoshi Matsumoto Yuichiro Yamashiro Hirotaka Watada |
| author_facet | Shoko Tamaki Akio Kanazawa Junko Sato Yoshifumi Tamura Takashi Asahara Takuya Takahashi Satoshi Matsumoto Yuichiro Yamashiro Hirotaka Watada |
| author_sort | Shoko Tamaki |
| collection | DOAJ |
| description | <h4>Objective</h4>To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyzed regarding the clinical parameters associated with bacterial translocation defined as detection of bacteremia and levels of plasma lipopolysaccharide binding protein (LBP), the latter of which is thought to reflect inflammation caused by endotoxemia.<h4>Results</h4>LBP level was not significantly different between patients with and without bacteremia. No clinical factors were significantly correlated with the detection of bacteremia. On the other hand, plasma LBP level was significantly correlated with HbA1c (r = 0.312), fasting blood glucose (r = 0.279), fasting C-peptide (r = 0.265), body mass index (r = 0.371), high-density lipoprotein cholesterol (r = -0.241), and inflammatory markers (high-sensitivity C-reactive protein, r = 0.543; and interleukin-6, r = 0.456). Multiple regression analysis identified body mass index, HbA1c, high-sensitivity C-reactive protein, and interleukin-6 as independent determinants of plasma LBP level.<h4>Conclusion</h4>The plasma LBP level was similar in patients with and without bacteremia. While both bacteremia and LBP are theoretically associated with bacterial translocation, the detection of bacteremia was not associated with LBP level in T2DM. |
| first_indexed | 2024-12-21T23:11:22Z |
| format | Article |
| id | doaj.art-34599d65643c4525aa37cd867afe7ee9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T23:11:22Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-34599d65643c4525aa37cd867afe7ee92022-12-21T18:47:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01149e022259810.1371/journal.pone.0222598Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study.Shoko TamakiAkio KanazawaJunko SatoYoshifumi TamuraTakashi AsaharaTakuya TakahashiSatoshi MatsumotoYuichiro YamashiroHirotaka Watada<h4>Objective</h4>To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyzed regarding the clinical parameters associated with bacterial translocation defined as detection of bacteremia and levels of plasma lipopolysaccharide binding protein (LBP), the latter of which is thought to reflect inflammation caused by endotoxemia.<h4>Results</h4>LBP level was not significantly different between patients with and without bacteremia. No clinical factors were significantly correlated with the detection of bacteremia. On the other hand, plasma LBP level was significantly correlated with HbA1c (r = 0.312), fasting blood glucose (r = 0.279), fasting C-peptide (r = 0.265), body mass index (r = 0.371), high-density lipoprotein cholesterol (r = -0.241), and inflammatory markers (high-sensitivity C-reactive protein, r = 0.543; and interleukin-6, r = 0.456). Multiple regression analysis identified body mass index, HbA1c, high-sensitivity C-reactive protein, and interleukin-6 as independent determinants of plasma LBP level.<h4>Conclusion</h4>The plasma LBP level was similar in patients with and without bacteremia. While both bacteremia and LBP are theoretically associated with bacterial translocation, the detection of bacteremia was not associated with LBP level in T2DM.https://doi.org/10.1371/journal.pone.0222598 |
| spellingShingle | Shoko Tamaki Akio Kanazawa Junko Sato Yoshifumi Tamura Takashi Asahara Takuya Takahashi Satoshi Matsumoto Yuichiro Yamashiro Hirotaka Watada Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. PLoS ONE |
| title | Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. |
| title_full | Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. |
| title_fullStr | Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. |
| title_full_unstemmed | Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. |
| title_short | Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study. |
| title_sort | clinical factors associated with bacterial translocation in japanese patients with type 2 diabetes a retrospective study |
| url | https://doi.org/10.1371/journal.pone.0222598 |
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