The <i>WWOX/HIF1A</i> Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders

The <i>WWOX/HIF1A</i> Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders

Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX has been identified as a HIF1α regulator. <i>WWOX</i> downregulation leads to an increased expression of...

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Bibliographic Details
Main Authors:	Izabela Baryła, Ewa Styczeń-Binkowska, Elżbieta Płuciennik, Katarzyna Kośla, Andrzej K. Bednarek
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	International Journal of Molecular Sciences
Subjects:	glycolysis hypoxia-inducible factor 1α (HIF1α) WW domain-containing oxidoreductase (WWOX) metabolic disorders
Online Access:	https://www.mdpi.com/1422-0067/23/6/3326

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