Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders
The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association with oral cancer risk. The immunohistochemical...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14382 |
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| author | Lucas de Villalaín Saúl Álvarez-Teijeiro Tania Rodríguez-Santamarta Álvaro Fernández del Valle Eva Allonca Juan P. Rodrigo Juan Carlos de Vicente Juana M. García-Pedrero |
| author_facet | Lucas de Villalaín Saúl Álvarez-Teijeiro Tania Rodríguez-Santamarta Álvaro Fernández del Valle Eva Allonca Juan P. Rodrigo Juan Carlos de Vicente Juana M. García-Pedrero |
| author_sort | Lucas de Villalaín |
| collection | DOAJ |
| description | The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association with oral cancer risk. The immunohistochemical analysis of DcR2 and DEC1 expression (along with p16 and Ki67 expression) was carried out in 60 patients with clinically diagnosed oral leukoplakia. Fifteen cases (25%) subsequently developed an invasive carcinoma. Correlations between protein marker expression, histological grade and oral cancer risk were assessed. DcR2, DEC1 and Ki67 protein expressions were found to correlate significantly with increased oral cancer risk, and also with an increased grade of dysplasia. Multivariate analysis demonstrated that DcR2 and Ki67 expression are independent predictors of oral cancer development. Our results evidence for the first time the potential of DcR2 as an early biomarker to assess oral cancer risk in patients with oral leukoplakia (HR = 59.7, <i>p</i> = 0.015), showing a superior predictive value to histology (HR = 4.225, <i>p</i> = 0.08). These findings reveal that the increased expression of DcR2 and DEC1 occurred frequently in OPMDs. In addition, DcR2 expression emerges as a powerful biomarker for oral cancer risk assessment in patients with oral leukoplakia. |
| first_indexed | 2024-03-10T22:38:58Z |
| format | Article |
| id | doaj.art-345a3072819747e195363d4c12fd8b43 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:38:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-345a3072819747e195363d4c12fd8b432023-11-19T11:11:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181438210.3390/ijms241814382Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant DisordersLucas de Villalaín0Saúl Álvarez-Teijeiro1Tania Rodríguez-Santamarta2Álvaro Fernández del Valle3Eva Allonca4Juan P. Rodrigo5Juan Carlos de Vicente6Juana M. García-Pedrero7Department of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Oral and Maxillofacial Surgery, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainDepartment of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, SpainThe aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association with oral cancer risk. The immunohistochemical analysis of DcR2 and DEC1 expression (along with p16 and Ki67 expression) was carried out in 60 patients with clinically diagnosed oral leukoplakia. Fifteen cases (25%) subsequently developed an invasive carcinoma. Correlations between protein marker expression, histological grade and oral cancer risk were assessed. DcR2, DEC1 and Ki67 protein expressions were found to correlate significantly with increased oral cancer risk, and also with an increased grade of dysplasia. Multivariate analysis demonstrated that DcR2 and Ki67 expression are independent predictors of oral cancer development. Our results evidence for the first time the potential of DcR2 as an early biomarker to assess oral cancer risk in patients with oral leukoplakia (HR = 59.7, <i>p</i> = 0.015), showing a superior predictive value to histology (HR = 4.225, <i>p</i> = 0.08). These findings reveal that the increased expression of DcR2 and DEC1 occurred frequently in OPMDs. In addition, DcR2 expression emerges as a powerful biomarker for oral cancer risk assessment in patients with oral leukoplakia.https://www.mdpi.com/1422-0067/24/18/14382oral potentially malignant disordersoral leukoplakiasenescenceDcR2DEC1Ki67 |
| spellingShingle | Lucas de Villalaín Saúl Álvarez-Teijeiro Tania Rodríguez-Santamarta Álvaro Fernández del Valle Eva Allonca Juan P. Rodrigo Juan Carlos de Vicente Juana M. García-Pedrero Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders International Journal of Molecular Sciences oral potentially malignant disorders oral leukoplakia senescence DcR2 DEC1 Ki67 |
| title | Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders |
| title_full | Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders |
| title_fullStr | Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders |
| title_full_unstemmed | Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders |
| title_short | Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders |
| title_sort | emerging role of decoy receptor 2 as a cancer risk predictor in oral potentially malignant disorders |
| topic | oral potentially malignant disorders oral leukoplakia senescence DcR2 DEC1 Ki67 |
| url | https://www.mdpi.com/1422-0067/24/18/14382 |
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