Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccina...

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Bibliographic Details
Main Authors: Xintao Hu, Zhongyan Lu, Antonio Valentin, Margherita Rosati, Kate E. Broderick, Niranjan Y. Sardesai, Preston A. Marx, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Format: Article
Language:English
Published: Taylor & Francis Group 2018-09-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
hiv
siv
conserved sequences
vaccine
dna
immunization
infection
Online Access:http://dx.doi.org/10.1080/21645515.2018.1489949

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